TABLE 4

BMD in Women With a History of Self-Limited Delayed Puberty

Study (Reference)YearNSubgroupAge at Evaluation, Years ± SDOutcome VariableConclusion
LocationaBMD, g/cm2vBMD, g/cm3
Fox et al531993223071 ± 4.8
Late menarche (no criteria provided)Radius0.36Each year increment in age at menarche, postmenopausal BMD decreased by 0.9% (P = .02)
Early menarche (no criteria provided)Radius0.371
Tuppurainen et al55199553.4 ± 2.9
223Late menarche (>15 y)LS1.077LS and FN aBMD lower in late menarche vs early menarche group, all Ps <.05
FN0.896
1382Early menarche (<15 y)LS1.105
FN0.919
Chevalley et al62200962Later pubertal timing (menarche >12.94 y)8.9 ± 0.5Total body0.599aBMD lower in later vs earlier pubertal timing group at all sites, all Ps <.02
Radius0.445
FN0.636
LS0.630
20.4 ± 0.6Total body0.900
Radius0.701
FN0.838
LS1.026
62Earlier pubertal timing (menarche <12.94 y)9.0 ± 0.5Total body0.620
Radius0.456
FN0.658
LS0.651
20.4 ± 0.6Total body0.927
Radius0.719
FN0.878
LS1.060
Chevalley et al60200962Later pubertal timing (menarche >12.94 y)20.4 ± 0.6FN0.838FN and tibia aBMD and vBMD lower in later vs earlier pubertal timing group in both young adult and premenopausal women, all Ps <.004
Tibia0.314
6046.0 ± 3.7FN0.785
Tibia0.295
62Earlier pubertal timing (menarche <12.94 y)20.4 ± 0.6FN0.878
Tibia0.334
6045.6 ± 3.1FN0.825
Tibia0.322
  • aBMD, areal bone marrow density; DP, delayed puberty; FN, femoral neck; LS, lumbar spine; NS, not significant; vBMD, volumetric bone marrow density.