TABLE 5

Fracture Risk in Individuals With Delayed Puberty

Study (Reference)YearNameNAge at Evaluation, Years ± SDOutcome VariableConclusion
Johnell et al641995MEDOS2086 women78.1 ± 9.4Hip fractureRR: 1.45, 95% CI: 1.12 to 1.87 for age at menarche ≥15 y vs 11 y
Roy et al652003EPOS3173 men, 3402 women63.1 ± 7.8 (men), 62.2 ± 7.6 (women)Vertebral fractureRR: 1.8, 95% CI: 1.24 to 2.63 for age at menarche ≥16 y vs <16 y
Silman et al662003EPOS3173 men, 3402 women63.1 ± 7.8 (men), 62.2 ± 7.6 (women)Colles’ fractureRR: 1.5, 95% CI: 1.1 to 2.0 for age at menarche >15 y vs ≤15 y
Kindblom et al462006GOOD642 men18.9 ± 0.6Upper extremity fractureOR: 1.39, 95% CI: 1.08 to 1.79, P = .01 for each 1-y increment to PHV
Chevalley et al63201242 women20.4 ± 0.6FractureOR: 2.09, 95% CI: ∼1.3 to 3.3, P = .002 for each 1.2-y delay in menarche; mean age at menarche greater for fracture group vs no fracture group (13.45 vs 12.78, P = .003)
  • CI, confidence interval; EPOS, European Prospective Osteoporosis Study; GOOD, Gothenburg Osteoporosis and Obesity Determinants; MEDOS, Mediterranean Osteoporosis Study; OR, odds ratio; RR, relative risk; PHV, peak height velocity.