TABLE 3

BMD in Men With a History of Self-Limited Delayed Puberty

Study (Ref)YearDelayed Puberty CriteriaSubgroupNAge at Evaluation, Years ± SDOutcome VariableConclusion
LocationaBMD, g/cm2vBMD, g/cm3
Finkelstein et al441992Puberty onset >15 y as defined by pubic hair stage and heightDP2326 ± 2Radius0.730.5aBMD and vBMD lower in DP vs normal controls at both sites, all Ps < .009
LS1.030.13
Controls2124 ± 3Radius0.80.54
LS1.130.14
Bertonelloni et al241998Testicular vol 4 mL achieved at ≥14 yDP2121.8 ± 1.7LS1.1010.327aBMD lower in DP vs normal controls, P < .009; no difference in vBMD, P = NS
Controls1219.3 ± 1.3LS1.2220.337
Yap et al482004Testicular vol 4 mL achieved at ≥14 yDP3224.7 ± 3.4Total body1.184Total body aBMD lower in DP vs controls, P = .016; LS aBMD lower in DP vs controls, P = .044, no difference in LS vBMD, P = NS; no difference in FN aBMD or vBMD
LS1.20.37
FN1.10.67
Controls4523.5 ± 2.9Total body1.237
LS1.280.37
FN1.160.67
Kindbloom et al462006PHV in the latest tertileLate-tertile PHV21418.9 ± 0.5Total body1.23Total body aBMD lower in late PHV versus average PHV, P = .001; no difference in LS or FN aBMD; radius aBMD and vBMD lower in late PHV versus average PHV, P all <0.001; tibia vBMD lower in DP versus controls, P all < 0.001
LS1.21
FN1.14
Radius0.56Cort: 1.155; Trab: 0.209
TibiaCort: 4.36; Trab: 0.254
Middle-tertile PHV21418.9 ± 0.5Total body1.25
LS1.24
FN1.18
Radius0.58Cort: 1.165; Trab: 0.221
TibiaCort: 4.44; Trab: 0.267
Kuh et al472016Lack of or limited genital development, voice breaking, and pubic hair growthPreadolescent at 14.5 y6560–64RadiusCort: 1.162; Trab: 0.197Trab vBMD lower in "preadolescent" by 9% vs "fully mature," 95% CI 14% to –4%; P = .001
LS1.01
Total hip0.97
Early puberty at 14.5 y22260–64RadiusCort: 1.161; Trab: 0.201
LS1.05
Total hip0.99
Advanced puberty at 14.5 y20060–64RadiusCort: 1.159; Trab: 0.205
LS1.04
Total hip1.00
Fully mature at 14.5 y16860–64RadiusCort: 1.153; Trab: 0.216
LS1.08
Total hip1.02
  • aBMD, areal bone marrow density; CI, confidence interval; Cort, cortical; DP, delayed puberty; FN, femoral neck; LS, lumbar spine; NS, not significant; PHV, peak height velocity; Trab, trabecular; vBMD, volumetric bone marrow density; —, not available.