Outcomes of Postnatal Treatment of CT According to the NCCCT Study

Treatment Outcome for Infants With CT With No/Mild Findings at Birth (n = 24), % (n/n)Treatment Outcome for Infants With CT With Severe Findings at Birth (n = 96),a % (n/n)
Normal motor-neurologic outcomes100 (13/13)80 (44/55)
Normal cognitive outcome (IQ >70)100 (13/13)73 (48/66)
No decreased IQ of ≥15 points between any 2 consecutive evaluations92 (12/13)84 (46/55)
Normal auditory outcome100 (13/13)100 (55/55)
No vision impairment85 (11/13)15 (8/55) (in the remaining 85% with vision impairment, the responsible lesion was already present at birth)
No recurrence of eye disease91 (10/11)64 (30/47)
  • Adapted from ref 110. Follow-up outcome ascertainment was not available for all children in each of the 2 groups. (Different outcomes were ascertained at different time points: for example, the endpoint of IQ <70 was evaluated at ≥3.5 y of age; the new eye lesions endpoint was evaluated at ≥7.5 y of age; all other endpoints were evaluated at ≥5 y of age.)

  • a Infants were classified in the severe stratum if there were ≥3 punctate focal calcifications or abnormal density of white matter in initial CT scan findings, seizures, motor abnormalities, hydrocephalus, microcephalus, elevated CSF protein, hypoglycorrhachia, macular scarring, optic nerve atrophy, visual impairment, microphthalmia, a CSF T gondii–specific antibody production ratio >1, or hearing loss.