TABLE 3

Number of Immunogenic Proteins and Polysaccharides Contained in Vaccines Over the Past 100 Years

1890196019802000
VaccineProteinsVaccineProteinsVaccineProteinsVaccineProteins and Polysaccharides
Smallpox∼200Smallpox∼200Diphtheria1Diphtheria1
Total∼200Diphtheria1Tetanus1Tetanus1
Tetanus1WC-pertussis∼3000AC-pertussis2–5
WC-pertussis∼3000Polio15Polio15
Polio15Measles10Measles10
Total∼3217Mumps9Mumps9
Rubella5Rubella5
Total̴3041Hib2
Varicella69
Pneumococcus8
Hepatitis B1
Total123–126
  • Adapted from Offit et al.52

  • AC-pertussis, acellular pertussis vaccine; WC-pertussis, whole cell pertussis vaccine.