TABLE 1

Patient and IH Characteristics

CharacteristicValue
Patients, N = 731
Sex
  Female530 (72.6)
  Male200 (27.4)
 Age at TTM initiation, mo
  0–3284 (41.2)
  3–6199 (28.8)
  6–980 (11.6)
  9–1237 (5.4)
  >1290 (13.0)
 Previous therapy
  Yes95 (13.7)
  No598 (86.3)
 Mean treatment duration, mo9.47
IHs
Location (no. of patients = 727)
  Head and neck582 (80.1)
  Body145 (19.9)
Morphology (no. of patients = 714)
  Localized572 (80.1)
  Segmentala80 (11.2) [2 PHACEb, 1 LUMBARc]
  Indeterminated62 (8.7)
IH subtype (no. of patients = 722)
  Superficial405 (56.1)
   <1 mm thick139 (34.8)
   1–3 mm thick171 (42.9)
   >3 mm thick89 (22.3)
  Deep28 (3.9)
  Combined/mixed289 (40.0)
  Mainly superficial96 (33.6)
  Equally superficial and deep85 (29.7)
  Mainly deep105 (36.7)
  • Unless otherwise indicated, values are given as n (%).

  • a Segmental IHs are those that encompass a patterned, geographic, and often broad territory of skin involvement and are more likely to be associated with systemic abnormalities and complications.

  • b Posterior fossa malformation, hemangioma, arterial anomolies, coarctation of aorta, and eye abnormalities.

  • c Lower body hemangioma and other cutaneous defects, urogenital anomalies, ulceration, myelopathy, bony deformities, anorectal malformations, arterial anomalies, and renal anomalies.

  • d Indeterminate IHs are those thought to represent a small portion of a defined segmental pattern.