TABLE 4

Maternal Death and Severe Morbidity Among Women Who Delivered a Singleton Infant With and Without NAS in Canada (Excluding Quebec) From 2005–2006 to 2015–2016

Maternal Death or Severe MorbidityInfant With NASInfant Without NASOR (95% CI)aOR (95% CI)aARD per 10 000 Live Births (95% CI)
nRate per 10 000nRate per 10 000
Maternal death<5<0.05890.316.48 (1.60 to 26.30)6.53 (1.59 to 26.74)1.71 (0.18 to 7.98)
Eclampsia1110.9714955.182.13 (1.17 to 3.84)1.89 (1.01 to 3.52)4.61 (0.05 to 13.05)
Acute cardiac morbidity2423.94330811.452.10 (1.40 to 3.13)1.95 (1.28 to 2.97)10.88 (3.21 to 22.56)
Cardiomyopathy87.985611.944.11 (2.05 to 8.27)4.04 (2.00 to 8.14)5.90 (1.94 to 13.85)
Shock98.987082.453.67 (1.90 to 7.08)3.63 (1.88 to 7.02)6.44 (2.16 to 14.75)
Obstetric embolism109.977802.703.70 (1.98 to 6.90)2.99 (1.49 to 6.01)5.37 (1.32 to 13.53)
Central nervous system morbidity54.993251.134.44 (1.84 to 10.73)5.38 (2.21 to 13.06)4.95 (1.37 to 13.63)
Disseminated intravascular coagulation<5<0.051980.69−0.69 (–0.78 to –0.59)b
Adult RDS<5<0.051130.392.55 (0.36 to 18.26)2.52 (0.35 to 18.11)0.59 (−0.25 to 6.67)
Acute abdomen<5<0.052130.741.35 (0.19 to 9.65)1.31 (0.18 to 9.39)0.23 (−0.61 to 6.21)
Hepatic failure<5<0.05600.2114.41 (4.52 to 45.95)14.31 (4.43 to 46.27)c2.80 (0.72 to 9.51)c
Renal failure76.986792.352.97 (1.41 to 6.26)2.63 (1.25 to 5.56)3.83 (0.59 to 10.72)
Sepsis2928.9225708.903.26 (2.26 to 4.70)2.99 (2.06 to 4.35)17.71 (9.43 to 29.82)
Antepartum hemorrhage with blood transfusion2827.9222377.743.61 (2.49 to 5.25)3.67 (2.51 to 5.38)20.67 (11.69 to 33.90)
PPH or placenta accreta with blood transfusion106105.7115 78354.631.95 (1.61 to 2.36)1.87 (1.54 to 2.27)47.53 (29.50 to 69.38)
Status asthmaticus<5<0.05560.195.15 (0.71 to 37.17)5.23 (0.72 to 38.08)0.80 (−0.05 to 7.05)
Status epilepticus<5<0.05720.254.00 (0.56 to 28.80)5.56 (0.76 to 40.49)c1.14 (–0.06 to 9.87)c
Acute psychosis<5<0.051100.385.25 (1.30 to 21.23)5.15 (1.26 to 20.99)1.58 (0.10 to 7.60)
Uterine scar dehiscence or rupture98.98296910.280.87 (0.45 to 1.68)0.86 (0.41 to 1.81)−1.44 (–6.07 to 8.33)
Complications of anesthesia or procedures<5<0.053561.231.62 (0.40 to 6.50)1.92 (0.48 to 7.72)1.13 (–0.64 to 8.27)
Potentially life-saving interventions207206.4422 46577.762.69 (2.34 to 3.09)2.49 (2.16 to 2.87)115.86 (90.20 to 145.41)
 Hysterectomy2120.94394313.651.54 (1.00 to 2.36)1.74 (1.12 to 2.70)10.10 (1.64 to 23.21)
 Repair of bladder, urethra, or intestine76.9819376.711.04 (0.50 to 2.19)1.11 (0.53 to 2.33)0.74 (–3.15 to 8.92)
 Blood transfusion184183.5019 15866.322.80 (2.42 to 3.24)2.56 (2.20 to 2.97)103.46 (79.58 to 130.65)
 Assisted ventilation2019.9513994.844.13 (2.65 to 6.42)3.99 (2.56 to 6.23)14.47 (7.55 to 25.31)
 Evacuation of incisional hematoma<5<0.056532.261.77 (0.66 to 4.72)1.88 (0.70 to 5.04)1.99 (–0.68 to 9.13)
Mortality or severe morbidity (without transfusion)d251250.3234 030117.802.16 (1.90 to 2.45)2.09 (1.84 to 2.37)128.40 (98.95 to 161.39)
Mortality or severe morbidity311310.1638 927134.752.34 (2.09 to 2.63)2.21 (1.97 to 2.49)163.05 (130.71 to 200.78)
  • Cells with <5 observations were not reported because of confidentiality reasons. PPH, postpartum hemorrhage; —, not applicable.

  • a Adjusted for maternal age, year of birth, rural residence, socioeconomic quintile, infant sex, prepregnancy chronic hypertension, and prepregnancy diabetes.

  • b Unadjusted RD.

  • c Not adjusted for prepregnancy chronic hypertension and prepregnancy diabetes because of collinearity.

  • d Does not include women with blood transfusions and without any other indication of severe morbidity.