TABLE 1

Factors Implicated in the Pathogenesis of Apnea of Prematurity

Central MechanismsPeripheral Reflex Pathways
Decreased central chemosensitivityDecreased carotid body activity
Hypoxic ventilatory depressionIncreased carotid body activity
Upregulated inhibitory neurotransmittersLaryngeal chemoreflex
Delayed central nervous system developmentExcessive bradycardic response