TABLE 4

Multivariable Logistic Regression Results for the Association of Antibiotic Episodes at <24 Months of Age and Risk for Overweight and/or Obesity at 48–<72 Months of Age, by Courses of Antibiotics

EpisodesNo Complex Chronic Condition, N = 310 947Complex Chronic Condition, N = 51 603
Model 1,a OR (95% CI)Model 2,b OR (95% CI)Model 1,a OR (95% CI)Model 2,b OR (95% CI)
Any antibiotic
 01.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 11.04 (1.02 to 1.06)1.01 (0.99 to 1.03)1.05 (1.00 to 1.11)1.01 (0.96 to 1.07)
 21.11 (1.09 to 1.14)1.06 (1.03 to 1.09)1.10 (1.03 to 1.17)1.03 (0.96 to 1.10)
 31.14 (1.10 to 1.17)1.07 (1.04 to 1.11)1.06 (0.98 to 1.14)0.98 (0.91 to 1.06)
 4+1.17 (1.14 to 1.20)1.10 (1.07 to 1.13)1.14 (1.08 to 1.20)1.03 (0.97 to 1.10)
Broad spectrum
 01.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 11.10 (1.08 to 1.12)1.06 (1.04 to 1.09)1.08 (1.03 to 1.14)1.04 (0.99 to 1.10)
 21.12 (1.09 to 1.16)1.07 (1.04 to 1.10)1.14 (1.07 to 1.23)1.09 (1.01 to 1.17)
 31.11 (1.07 to 1.16)1.06 (1.02 to 1.11)1.17 (1.07 to 1.28)1.12 (1.02 to 1.22)
 4+1.14 (1.10 to 1.18)1.09 (1.05 to 1.12)1.13 (1.06 to 1.21)1.05 (0.97 to 1.13)
Narrow spectrumc
 01.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 11.03 (1.01 to 1.06)1.00 (0.98 to 1.03)1.02 (0.95 to 1.09)0.98 (0.91 to 1.05)
 21.09 (1.05 to 1.12)1.04 (1.00 to 1.08)1.04 (0.93 to 1.15)0.98 (0.88 to 1.09)
 31.12 (1.05 to 1.18)1.06 (1.00 to 1.12)1.03 (0.87 to 1.22)0.94 (0.79 to 1.12)
 4+1.15 (1.07 to 1.25)1.07 (0.99 to 1.16)0.84 (0.68 to 1.04)0.78 (0.63 to 0.96)
  • OR, odds ratio.

  • a Corrected for clustering by site.

  • b Corrected for clustering by site and adjusted for sex, race, ethnicity, preterm birth, asthma, corticosteroid episodes (continuous, 0–4+) at 0–<24 months of age, number of encounters (continuous, log transformed) at 0–<24 months of age, infection episodes (continuous, log transformed) at 0–<24 months of age, and age at outcome.

  • c For narrow antibiotic exposures, analyses were limited to participants with no broad-spectrum antibiotics during the same time window as exposure or before.