TABLE 3

Multivariable Logistic Regression Analyses to Predict the Risk of Postvaccination Presyncope Defined by the Primary and Restrictive Outcomes

Primary Outcomea aOR (95% CI)Restrictive Outcomea aOR (95% CI)
Age, y
 <152.27 (1.79–2.88)2.84 (1.83–4.39)
 ≥15ReferenceReference
Sex
 MaleReferenceReference
 Female1.20 (0.97–1.48)1.03 (0.71–1.51)
Passed out or nearly passed out from shot or blood draw in the past 5 y
 NoReferenceReference
 Yes1.91 (1.27–2.87)2.70 (1.48–4.91)
Hunger or thirst
 Not at all or a little bitReferenceReference
 Very1.15 (0.90–1.47)1.46 (0.97–2.19)
Prevaccination anxiety
 None or slightReferenceReference
 Mild, moderate, or severe1.86 (1.45–2.38)2.77 (1.82–4.20)
No. of injectable vaccines
 1ReferenceReference
 >11.53 (1.24–1.89)1.95 (1.33–2.86)
Receipt of HPV vaccine
 NoReferenceReference
 Yes1.03 (0.83–1.28)1.00 (0.68–1.48)
Pain intensity
 0–1ReferenceReference
 2–52.96 (2.21–3.98)4.96 (3.34–7.36)
Group
 ControlReferenceReference
 Intervention0.92 (0.75–1.13)0.84 (0.58–1.21)
  • The outcomes were adjusted for each listed variable and enrollment center. aOR, adjusted odds ratio.

  • a The primary outcome is “a little bit” or more in response to any of the 12 items on the presyncope instrument. The restrictive outcome is “somewhat” or more in response to any of the 12 items on the presyncope instrument.