TABLE 4

Accuracy of POX for Detection of Major CHD by Age in Asymptomatic Newborn Infants

6–12 h13–18 h19–24 h25–36 h37–48 h49–60 h61–72 h
N = 167 19014 93320 73742 38232 66928 23714 16414 068
True-positives1192118101110
False-negatives982221151721
False-positives3944664623117
True-negatives14 87420 67642 27332 58428 18814 12514 030
FPR (%)0.260.210.160.140.080.080.05
Sensitivity (95% CI)55.0 (34.2–74.2)52.9 (31.0–73.8)48.8 (34.6–63.3)46.2 (31.6–61.4)40.0 (23.4– 59.3)39.3 (23.6–57.6)32.3 (18.6–49.9)
Specificity (95% CI)99.7 (99.6–99.8)99.8 (99.7–99.8)99.8 (99.8–99.9)99.9 (99.8–99.9)99.9 (99.9–100.0)99.9 (99.9–100.0)100.0 (99.9–100.0)
  • Data are number or percentage (95% CI). Major CHD includes CCHD and serious defects. CI, confidence interval.