TABLE 2

Accuracy of Screening Methods for Detecting CCHD and Major CHD in Asymptomatic Newborns (N = 167 190)

CCHDMajor CHDa
POX AloneCardiac Auscultation alonePOX Plus Cardiac AuscultationPOX AloneCardiac Auscultation AlonePOX Plus Cardiac Auscultation
True-positives34334290170187
False-negatives101121133316
False-positives2921748200523616111860
True-negatives166 854165 398165 141166 751165 376165 127
FPR (%)0.21.11.20.11.01.1
Sensitivity (%)77.3 (63.0–87.2)75.0 (60.6–85.4)95.5 (84.9–98.7)44.3 (37.7–51.2)83.7 (78.1–88.2)92.1 (87.6–95.1)
Specificity (%)99.8 (99.8–99.8)99.0 (98.9–99)98.8 (98.8–98.9)99.9 (99.8–99.9)99.0 (99.0–99.1)98.9 (98.8–98.9)
Positive predictive value (%)10.4 (7.6–14.2)1.9 (1.3–2.6)2.1 (1.5–2.8)27.6 (23.0–32.7)9.5 (8.3–11.0)9.1 (8.0–10.5)
Negative predictive value (%)100.0 (100.0–100.0)100.0 (100.0–100.0)100.0 (100.0–100.0)99.9 (99.9–99.9)100.0 (100.0–100.0)100.0 (100.0–100.0)
Diagnostic accuracy (%)99.8 (99.8–99.8)99.0 (98.9–99.0)98.8 (98.8–98.9)99.8 (99.8–99.8)99.0(99.0–99.1)98.9 (98.8–98.9)
Positive likelihood ration442.3 (432.0–452.9)71.7 (70.2–73.2)79.6 (79.3–79.8)313.7 (302.7–325.1)86.8 (86.5–87.1)82.7 (82.5–82.9)
Negative likelihood ratio0.2 (0.2–0.3)0.3 (0.2–0.3)0.1 (0.0–0.1)0.6 (0.6–0.6)0.2 (0.2–0.2)0.1 (0.1–0.1)
  • Data are number or percentage (95% confidence interval).

  • a Major CHD includes CCHD and serious defects.