TABLE 1

Characteristics of included studies

StudyCountryStudy SiteStudy DesignSample SizeStudy DurationPatient CharacteristicsFeeding Categories, nROP Diagnosis
Gestational Age, wkBirth Weight, gOther Factors Reported
Hylander et al, 200121usNICU, university hospitalCohort174January 1992 to September 1993Prenatal care, health insurance, maternal smoking, alcohol use, illegal drug useStages 1–4
 Human milk28.0 ± 2.21044 ± 251100%, 17; 80%–90%, 28; 20%–79%, 39; <20%, 16
 Formula27.5 ± 2.4948 ± 22374
Furman et al, 200322USNICU, university hospitalCohort119January 1997 to February 1999Ethnicity, ventilator dependenceStages 1–4
 Human milk28 ± 2mL/kg/day: 1–24, 914 ± 205; 25–49, 988 ± 248; >50, 1163 ± 225mL/kg/day: 1–24, 29; 25–49, 18; >50, 32
 Formula28 ± 2 1103 ± 26040
Heller et al, 200718USNICU, multicenter university hospitalsCohort1057October 1999 to September 2001Pneumothorax, ethnicity, maternal hypertension, day of first feeding, human milk proportion, antenatal steroidsSurgical ROP
 Human milk26.0 ± 2775 ± 134788
 Formula26.2 ± 2783 ± 140269
Maayan-Metzger et al, 201223IsraelNICU, university hospitalCohort3602006 to 2008Small for gestational age, gender, multiple pregnancy, mechanical ventilationStages 1–3
 Human milk30.5 (24–32)1305 ± 388>50%, 188
 Formula31 (24–32)1425 ± 398>50%, 172
Manzoni et al, 201317ItalyNICU, multicenter hospitalsCohort4982004 to 2008Hyperglycemia
 Human milk29.4 ± 2.51125 ± 247314All stages ROP
 Formula29.2 ± 2.81100 ± 272184Threshold ROP