TABLE 3

Narrative Summary of the Main Findings of 10 Outpatient Trials in Terms of Effects of HS on Improving Clinical Scores

TrialScoring MethodsMain Findings
Al-Ansari 201014Wang score- Mean scores (SD) 24 h after randomization: 5% saline vs 0.9% saline: 3.75 (1.27) vs 3.97 (1.40), P > .05; 3% saline vs 0.9% saline: 4.0 (0.98) vs 3.75 (1.27), P > .05.
- Mean scores (SD) 48 h after randomization: 5% saline vs 0.9% saline: 3.69 (1.09) vs 4.12 (1.11), P = .04; 3% saline vs 0.9% saline: 4.0 (1.22) vs 4.12 (1.11), P > .05.
- Consistent trend favoring 5% saline from 8 to 72 h after randomization.
Anil 201015Wang scoreThere was no significant difference between 3% and 0·9% saline groups in terms of clinical scores at 30, 60, and 120 min of assessment.
Florin 201431RDAI score- Mean RDAI scores (95% CI) 1 h after saline administration: 3% saline vs 0.9% saline: 6.6 (5.5–7.6) vs 5.1 (4.1–6.2), P = .05.
- Mean RACS scores (95% CI) 1 h after saline administration: 3% saline vs 0.9% saline: −1.5 (−3.1–0.2) vs −4.0 (−5.3 to −2.7), P = .01.
Grewal 200913RDAI scoreMean RACS scores (95% CI) from 0 to 120 min: 3% saline vs 0.9% saline: 4.39 (2.64–6.13) vs 5.13 (3.71–6.55), P > .05.
Ipek 201117Wang scoreThere was no significant difference between 3% and 0.9% saline groups in terms of clinical scores at 60 min of assessment.
Jacobs 201432Wang score- Mean change in scores (SD) at ED disposition: 7% saline vs 0.9% saline: 2.6 (1.9) vs 2.4 (2.3), P = .21.
- Mean change in scores (SD) after first nebulization in ED disposition: 7% saline vs 0.9% saline: 2.06 (1.7) vs 2.0 (1.9), P = .06.
Li 201435Wang scoreMedian scores (interquartile range): 5%, 3% vs 0.9% saline.
−24 h after treatment: 6 (1), 6 (1) vs 7 (1); P < .05 (5% vs 0.9%; 3% vs 0.9%).
−48 h after treatment: 5 (1), 5 (1) vs 6 (0.2), P < .05 (5% vs 0.9%).
−72 h after treatment: 3.5 (1), 4 (1) vs 7 (0), P < 0·05 (5% vs 0.9%; 3% vs 0.9%).
Sarrell 20029Wang scoreMean scores differed significantly, in favor of 3% saline compared with 0.9% saline, on each of the treatment days.
Wu 201430RDAI scoreMean scores (SD): 3% saline vs 0.9% saline: 5.32 (3.14) vs 4.88 (2.95), P > .05.
NCT 0127682136Wang scoreMean change in scores (SD) after 2 sessions of nebulization: 3% saline vs 0.9% saline: 3.52 (1.41) vs 2.26 (1.15)