TABLE 1

Characteristics of Included Studies

Study IDStudy DesignCountryDomains AssessednHIV+tHIV+eHIV+eHIV–uHIV–HIV-Infected, NControls, NTotal, N
Angelini (20)NRItalyGIQ, visual-spatial ability, visuomotor coordination1110062062
Boivin (21)NRUgandaLearning, psychomotor speed, working memory, attention1100028060
Boivin 2010 (22)NRUgandaMemory, visual-spatial processing, immediate and delayed memory, executive function100001020102
Cohen (23)aCross-sectionalNetherlandsGIQ (VIQ + PIQ), processing speed, attention, working memory, executive function11101353772
Franklin (24)LongitudinalNRGIQ0100039039
Fundaro (25)NRItalyMemory, visual-spatial ability, language, learning, spatial organization010108816
Hoare (7)Cross-sectionalSouth AfricaInformation processing speed, attention, working memory, visual attention, executive function0100050050
Hoare (6)aCross-sectionalSouth AfricaGIQ, motor coordination, information processing speed, attention, working memory, visual-spatial ability, visual memory, executive function10001121224
Kandawasvika (26)aCross-sectionalZimbabweGIQ, information processing, numeracy, memory, motor ability1101132274306
Keller (27)aNRUSVisual-spatial ability, visual memory, language, learning, motor coordination11100201333
Koekkoek (28)NRNetherlandsGIQ, working memory, attention, information processing, executive function, visual-spatial perception1100122022
Llorente (29)LongitudinalUSExecutive function, attention, working memory, visual-spatial ability011107685161
Llorente (30)NRUSLanguage, information processing speed0100022022
Martin (31)Cross-sectionalUSGIQ (VIQ + PIQ)0100041041
Nichols (32)Cross-sectionalUSVisual and verbal memory and learning0111017385258
Nozyce (33)RCTUSGIQ (VIQ + PIQ)010002740274
Puthanakit (34)RCTThailandGIQ, memory, motor coordination11011284319603
Ravindrin (35)aNRIndiaAttention, language, visual memory, verbal learning, verbal memory, visual perceptual/spatial ability, visuomotor function, fine motor skills, executive function01001202040
Rice (36)Prospective cohortUSLanguage01011284153437
Ruel (37)aNRUgandaAttention, GIQ, motor proficiency10001161106267
Smith (4)NRUSGIQ, verbal comprehension, perceptual reasoning, working memory, processing speed01110358200558
Walker (38)Case-controlJamaicaGIQ, memory, attention, fine motor coordination111002870287
  • 1, yes; 0, no; eHIV+, encephalopathy HIV-infected; eHIV–, exposed HIV-uninfected; GIQ, general IQ/functioning; nHIV+, HAART naive HIV-infected; NR, not reported; PIQ, performance IQ; tHIV+, HAART-treated HIV-infected; uHIV–, unexposed HIV-uninfected; VIQ, verbal IQ.

  • a Denotes the studies included in the meta-analysis.