TABLE 2

List of Studies Identified and Selected Through Database Searches

First Author and ReferenceTarget Dose of PropranololPlanned Initiation (Uptitration) Dose(s)End of Treatment Tapering DetailsTreatment Duration in Completers, mo
mg/kg per dayRegimenmg/kg per dayUptitration Regimen; DurationnaMeanMedianMinMax
Ábarzúa-Araya262TID106
Al Dhaybi312–3TID0.5, 1, 1.5TID; incremental increases by 0.5 mg/kg per day every 4 d17
Albuquerque322–4BID/TID0.5+BID/TID; 0.5 mg/kg per day (D1–D7) then weekly increases3711127
Andersen331–2BID/TID12 wk (half dose)166.751.512
Bagazgoitia342BID714.7
Balma-Mena352–3TID0.3, 0.6, 1.2TID; doubled every 3 d for 2 wk167.2
Bauman242TID910.6
Ben-Amitaï362BID0.5+TID; uptitrated over 3 d109.7513
Bernabeu-Wittel372BID0.5, 1.0, 1.5BID; increase of 0.5 every 3 d288.7216
Bertrand382–3TID0.5, 1.0, 1.5TID; increase of 0.5 every 4 d358.9113
Betlloch-Mas392TID1 mg/kg per day for 2 wk and 0.5 mg/kg per day for 2 wk20314
Blatt401–4BID/TID0.25–1BID/TIDYes54
Buckmiller412TIDNo uptitrationHalf dose for 1 to 2 wk325.5210
Celik422BIDHalf dose for 2 wk498.3318
Chai4320.5, 1.0TID: 0.5 mg/kg per day then doubled every day over 3 dOver 2 wk273.832.755.75
Cheng442BID/TIDNo uptitration37.52.89.8
Chik452TID0.5, 1.0TID; doubled every day over 3 d1226
Claerhout462BID1BID; to D10–D14107.67.6
Corapcioğlu472TIDNo uptitration12549
Cushing482–3TID0.5–0.7First dose; follow-up for 3 h after first dose44
Dyme493TIDNo uptitration152.80.210
El Ezzi502TID1, 2TID; D1, D2297.1416
El-Essawy511–2TID0.48+TID; gradually increased over 2 wkYes157.67612
Erbay522–3TID1TID; for patients <3 kg161.56.5
Fuchsmann532–3TID0.5, 1,TID; for 2 d for each dose, then increased by 1 mg/kg per day every 2 d until final dose398.5
Gan3020.5, 1, 1.51-wk uptitration starting at 0.5 mg/kg per day on D1, at 1 mg/kg per day on D2, at 1.5 mg/kg per day on D3, then target dose if no AE109612
Georgountzou542BIDNo uptitration247.562.516
Giachetti551.5–2 (4 in 2 premature twins)TID1TID; D1–D730313
de Graaf191.8–4BID/TIDBID/TID; 1 mg/kg per day increased to 2 mg/kg per day after 5 doses, to 4 mg/kg per day if inadequate response68.54.517
Haider562TID0.5, 1, 1.5TID; increase by 0.5 mg/kg per day every 3 dOver 2-wk period17
Harper572TID1TID; for 1 wkHalf-dose twice every 2 wk30
Hasan583TID363.3627
Hassan593BID1BID; for 1 wk then increased to full dosageOver 4 wk309.4614
Hermans602.0–2.5TID0.7–1.0TID, increased over 3 d to target dose209.1
Hermans292.0–3.0TID0.7–1.0TID, gradually increased to target doseBID for 2 wk then QD for 1 wk17410.7
Hogeling232TID1TID; for 1 wkFor 2 wk (half-dose every week)196.3
Holmes613TID0.5, 1TID; 0.5 mg/kg if tolerated, then 1 mg/kg, then target dose312.920.2313.5
Hong622TID0.5+TID; uptitration of 1–2 wk456.5311
Hsu632–3BID/TID0.5, 1BID or TID; if tolerated, dose doubled at every weekly visit135.5314
Javia642TID0.5, 1TID; 0.5 mg/kg per day on D1, 1 mg/kg per day on D2129.64.513
Jian6521-2At initial dose97612
Kagami6621TID; D1–D71 mg/kg per day × 2 wk, 0.5 mg/kg per day × 2 wk15
Katona672TIDNo uptitration22614
Küpeli682BID146
Laforgia692BID/TIDNo uptitrationOver 2 mo118412
Leboulanger702–3146
Liu712TIDNo uptitration31
Luo272BID63518.6532
Lv722QD37336
Lynch732TID0.5, 1TID; 0.5 mg/kg per day (D1), 1 mg/kg per day (D2)4410.70.724.5
Ma740.75–1BID8913.6516
Mahadevan751–2BID107.7411
Malik251–3BID1 mg/kg per day BID (D1), 2 mg/kg per day at D2 if well tolerated, 3 mg/kg per day if not improved at 1 moOver the last month79.8316
Manunza762TID1TID; for 1 wk303.515
McGee771–2TID0.5, 1TID; 1 wk of uptitration from 1 mg/kg per day (23 infants) or 0.5 mg/kg per day (1 infant/PHACES)2410.53.514
McSwiney782BID; from D40.5, 1BID; 0.5 mg/kg per day (if normal exam), if no side effect discharge at 1 mg/kg per day BID for 3 d20
Meng791–1.5QD225
Metry801.8BID/TID3212.3
Missoi812TID0.5, 1TID; 0.5 mg/kg per day for 1 wk then 1 mg/kg per day for 1 wkFor 4 wk176.84.17.2
Ozyörük822BIDNo uptitration146312
Park832TID0.5, 1TID; 1 mg/kg per day at D2, 2 mg/kg per day at D3838.72.528
Phillips282BID1BID; for 3 d18881030
Price92BID/TID0.5, 1BID or TID; for 3 d eachFor 2 wk687.93.514
Puttgen842TID1TID; on D150
Rössler852BID1BID; on D1306.50.69.8
Sadykov862TID1TID; on D1714.7
Sagi872TID0.5TID; D1 and D2998.5215
Saint Jean882–3BID/TID335.9
Sans62–3BID/TIDNo uptitration326.1
Schiestl892TID1TID; on D11 mg for last 4 wk2510.57.516
Schupp902TID1TID; on D1; if well tolerated, increased to target dose555.8
Snir912BID307.31.515
Sondhi222BIDHalf the dose twice at 2-wk interval3172.811.7
Szychta922TID1TID; on D1 for age <2 y6010.5
Tan931.5–20.5, 1BID; 0.5 mg/kg per day on D1 then 1 mg/kg per day, then increased by 0.5 mg/kg per day until response or 2 mg/kg per day15
Vassallo942142.514
Vercellino952TID1TID; 1 mg/kg per day to lowest effective dose686
Weiss962BID11
Xiao212TIDNo uptitration648.54.514
Yuan971.5QD1QD; for 3 mo3548
Zaher982TID306214
Zegpi-Trueba992BIDNo uptitration577.3124
Zvulunov100423.618
  • BID, twice daily; D, day; Max, Maximum; Min, minimum; PHACES, posterior fossa brain anomalies, hemangiomas, arterial anomalies, and cardiac defects and coarctation of the aorta, eye abnormalities, and sternal abnormalities or ventral developmental defects; QD, once per day; TID, 3 times per day; —, not specified in the original article.

  • a Number of patients used to calculate duration of treatment (if available); otherwise, total number of patients treated is presented.