TABLE 1

Burden of Diseases Prevented by Vaccines Recommended for Adolescents in the United States As Reported by the Centers for Disease Control and Prevention

Annual Number of CasesAnnual Number of Deaths
Meningococcal diseasea1146115–172
Tetanusb294
Diphtheriac<1<1
Pertussisd20 04619
HPVe26 000 (cancer)6210 (cancer)
360 000 (genital warts)
  • a Average annual estimated number of cases of meningococcal disease during 2002–2011. Deaths were estimated by using the reported case-fatality ratio of 10% to 15%. Centers for Disease Control and Prevention. Prevention and Control of Meningococcal Disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2013;62:4-5 (No. RR-2).

  • b Average annual number of cases during 2001–2008. Deaths estimated using reported case-fatality ratio of 13.9%. Centers for Disease Control and Prevention. Tetanus surveillance—United States, 2001–2008. MMWR. 2011;60:365–369.

  • c Based on 2 cases reported 2004–2015. Available at: http://www.cdc.gov/diphtheria/about/index.html. Accessed July 27, 2017.

  • d Average annual number of cases reported 2000–2014 (range, 7580–48 277). Available at: www.cdc.gov/pertussis/surv-reporting/cases-by-year.html. Accessed July 27, 2016.

  • e Cancer cases reported during 2004–2008. Numbers are estimated from the actual number of diagnosed cases multiplied by the proportion attributable to HPV for each specific cancer (cervix, oropharynx, anus, vulva, vagina, penis). Estimate for deaths obtained by multiplying total number of cancer deaths in 2015 by the attributable proportion due to HPV. This estimate does not include oropharyngeal because mortality for head and neck cancers is not presented separately for this site. Centers for Disease Control and Prevention. Human papillomavirus-associated cancers—United States, 2004–2008. MMWR. 2012;61:258–261. Available at: www.seer.cancer.gov/statfacts and http://www.cdc.gov/std/hpv/stdfact-hpv.html (last accessed July 27, 2016).