TABLE 2

Clinical Associations of AP in 94 Children <15 Years Old in the United Kingdom

Clinical Associationn
Idiopathic35 (37%)
Drugs18 (19 %)
 Asparaginase5
 Azathioprine3
 Sodium valproate3
 Methylprednisolone1
 Mercaptopurine1
 Mesalazine1
 Carbamazepine1
 Clarithromycin1
 Opiates1
 Calcium carbonate/ alfacalcidol1
Gallstones12 (13%)
Hereditary7 (7%)
 SPINK1 gene positive5
 PRSS1 gene positive2
Organic acidemias7 (7%)
 Propionic acidemia4
 Methylmalonic acidaemia2
 Isovaleric acidaemia1
Anatomic anomalies5 (5%)
 Pancreas divisum3
 Choledochal cyst2
Viral infections3 (3%)
 Mumps1
 EBV and CMV1
 Rotavirus1
Systemic diseases2 (2%)
 Systemic lupus erythematosus1
 Henoch-Schonlein purpura1
Trauma1 (1%)
 Handlebar injury1
Others4 (4%)
 Cystic fibrosis2
 Hypertriglyceridaemia1
 α 1-antitrypsin deficiency1
  • CMV, cytomegalovirus; EBV, Epstein-Barr virus; PRSS1, Protease, Serine, 1 (Trypsin 1); SPINK1, Serine Peptidase Inhibitor, Kazal Type 1.