TABLE 3

Numbers and RRs Over Time, for Complex Congenital Heart Defects (Including AVSD, Aortic Arch Abnormality, Tetralogy of Fallot, or Transposition of the Great Arteries), and for AVSD, Isolated VSD, and Isolated ASD, Among 2588 Singleton Live-Born Infants With Down Syndrome, Born in Sweden 1992–2012

nRisk of Complex Congenital Heart DefectnRisk of AVSD
Crude RR(95% CI)Adjusted RRa(95% CI)Crude RR(95% CI)Adjusted RRa(95% CI)
Year of birth
 1992–19941611.00(ref)1.00(ref)1091.00(ref)1.00(ref)
 1995–19971251.03(0.86–1.22)1.02(0.84–1.24)891.06(0.85–1.33)1.04(0.81–1.34)
 1998–2000810.83(0.68–1.02)0.78(0.61–0.99)630.89(0.69–1.15)0.81(0.60–1.09)
 2001–20031010.81(0.67–0.98)0.82(0.66–1.01)890.94(0.75–1.18)0.93(0.73–1.20)
 2004–20061070.80(0.66–0.96)0.79(0.64–0.98)920.91(0.73–1.14)0.90(0.70–1.16)
 2007–2009920.74(0.60–0.90)0.74(0.59–0.92)850.88(0.70–1.11)0.87(0.67–1.13)
 2010–2012670.62(0.49–0.78)0.62(0.48–0.79)550.67(0.51–0.88)0.66(0.49–0.89)
Risk of VSDRisk of ASD
nCrude RR(95% CI)Adjusted RRa(95% CI)nCrude RR(95% CI)Adjusted RRa(95% CI)
Year of birth
 1992–1994331.00(ref)1.00(ref)291.00(ref)1.00(ref)
 1995–1997240.99(0.61–1.60)0.90(0.53–1.55)180.86(0.49–1.49)0.76(0.38–1.49)
 1998–2000361.46(0.95–2.24)1.12(0.68–1.85)261.25(0.77–2.04)1.49(0.86–2.57)
 2001–2003551.65(1.12–2.44)1.49(0.97–2.28)321.19(0.75–1.90)1.22(0.71–2.10)
 2004–2006641.74(1.19–2.55)1.55(1.02–2.36)311.08(0.68–1.74)1.09(0.63–1.88)
 2007–2009381.19(0.77–1.82)1.11(0.70–1.77)481.61(1.05–2.45)1.71(1.04–2.80)
 2010–2012571.71(1.16–2.52)1.48(0.97–2.26)401.45(0.93–2.25)1.52(0.92–2.52)
  • a Adjusted for year of birth, maternal age, parity, BMI, smoking, diabetes, hypertensive disease, and infant gender.