Histopathological Features of LE and TEN/SJS

EpidermalOrtho-/hyperkeratosis, atrophic epidermis, few necrotic keratinocytes at the dermo-epidermal junction, vacuolar degeneration of the basal keratinocytes, thickened basement membrane zoneNecrotic keratinocytes throughout, minimal vacuolar degeneration of basal keratinocytes
DermalModerate to dense, superficial and deep lymphocytic infiltrate, plasma cells, interstitial mucinSparse, superficial lymphocytic infiltrate
Adnexal involvementPeriadnexal lymphocytic infiltrate, vacuolar degeneration of hair follicle infundibulum with few necrotic keratinocytesFew to many necrotic keratinocytes without significant inflammatory infiltrate
  • Reprinted with permission from Ziemer M, Kardaun SH, Liss Y, Mockenhaupt M. Stevens-Johnson syndrome and toxic epidermal necrolysis in patients with lupus erythematosus: a descriptive study of 17 cases from a national registry and review of the literature. Br J Dermatol. 2012;166(3):577.