TABLE 1

Comparison of Characteristics Between Subjects With CF and CFSPID and Between Subjects With CFSPID Who Met the Criteria for CF During the Study Period (CFSPID→CF) and Those Who Remained Inconclusive (CFSPID→CFSPID)

AB
CF (n = 80)CFSPID (n = 82)PCFSPID→CF (n = 9)CFSPID→CFSPID (n = 73)P
Newborn characteristics
 Female gender, n (%)41 (51)43 (52).995 (56)34 (47).99
 Gestational age, mean (SD), wk38.8 (2.6)38.7 (2.1).838.4 (2.0)38.8 (2.7).7
 Birth weight, mean (SD), g3212 (544)3304 (670).363345 (974)3301 (651).89
 Newborn screening IRT, median (IQR), μg/L144 (105–199)77 (61–106)<.000184 (67–128)75 (60–103).2
Family history, n/N (%)
 CF17/76 (22)5/81 (6).0051 (11)4/72 (6).45
 Sinopulmonary disease21/47 (45)16/67 (24).0262 (22)14/58 (24).99
 Pancreatitis2/46 (4)2/68 (3).991 (11)1/59 (2).25
 Male infertility1/49 (2)1/70 (1).9901/62 (2).99
Baseline anthropometrics, mean (SD)
 Age at baseline assessment, mo1.1 (0.9)3.3 (5.1).00024.9 (6.8)3.2 (4.9).40
 Weight, z score−0.94 (1.0)0.03 (0.8)<.00010.68 (0.9)0.03 (0.9).10
 Height, z score−0.83 (1.0)0.04 (0.8)<.00010.29 (0.6)0.03 (0.9).58
 Head circumference, z score−0.05 (1.0)0.11 (2.0).130.53 (1.4)0.23 (2.0).83
Symptoms (reported by parents), n or n/N (%)
 Wheeze25 (31)10/81 (12).0041 (11)9/72 (13).99
 Cough60 (75)27/81 (33)<.00013 (33)24/72 (33).99
 Gastroesophageal reflux14 (18)7/81 (9).111 (11)6/72 (8).53
 Constipation16 (20)4/81 (5).00404/72 (6).99
 Abdominal pain29 (36)2/81 (3)<.000102/72 (3).99
Microbiology, n (%)
 Pseudomonas aeruginosa25 (31)10 (12).0043 (33)7 (10).07
 Staphylococcus aureus57 (71)33 (40)<.00013 (33)30 (41).65
 Haemophilus influenzae34 (43)33 (40).872 (22)31 (43).24
 Stenotrophomonas maltophilia8 (20)4 (5).242 (22)2 (3).05
 Aspergillus species1 (1)0.4900.99
 Streptococcus pneumoniae7 (9)4 (5).3704 (6).99
 Acinetobacter baumannii7 (9)1 (1).0301 (1).99
 Chryseobacterium indologenes9 (11)1 (1).00901 (1).99
 Coliforms48 (60)24 (29).00011 (11)23 (32).20
 No growth7 (9)22 (27)<.00013 (33)19 (26).64
  • IQR, interquartile range.