TABLE 1

Epidemiologic Studies Concerning NAIS

AuthorsDateType of RegistryDescriptionRegistrationCasesIncidence of NAIS and PPIS per 100 000 Live BirthsAges
Perlman et al181994Hospital-basedRetrospective analysis of hospital records, United States of AmericaAcutely (NAIS)NAIS: 8NAIS: 29All gestational ages
Estan and Hope171997Hospital-basedRetrospective analysis of hospital records, United KingdomAcutely (NAIS)NAIS: 11NAIS: 25>31 wk
Govaert et al162000Hospital-basedRetrospective analysis of ultrasound and MRI records, the NetherlandsAcutely (NAIS)NAIS: 40NAIS: 35All gestational ages
Lynch et al152002Population-basedNational Hospital Discharge Survey, United States of AmericaAcutely (NAIS)NAIS: NANAIS: 18All gestational ages
Wu et al22004Population-basedElectronic search for diagnosis within the Kaiser Permanente Medical Care Program birth cohort database, qualifying diagnoses by chart review, United States of AmericaAcutely (NAIS) and retrospectively (PPIS)NAIS and PPIS: 38NAIS and PPIS: 17>36 wk
NAIS: 12NAIS: 5
PPIS: 26PPIS: 12
Lee et al142005Population-basedElectronic search of head MRI and computed tomography reports, within the Kaiser Permanente Medical Care Program birth cohort database, United States of AmericaAcutely (NAIS) and retrospectively (PPIS)NAIS and PPIS: 40NAIS and PPIS: 20All gestational ages
NAIS: 23NAIS: 12
PPIS: 17PPIS: 8
Schulzke et al132005Hospital-basedRetrospective analysis of hospital records, SwitzerlandAcutely (NAIS)NAIS: 5NAIS: 43All gestational ages
Laugesaar et al122007Population-basedRetrospective analysis of hospital records; prospective registration of new cases (partly); inquiry among child neurologists and general practitioners; EstoniaAcutely (NAIS) and retrospectively (PPIS)aNAIS: 4NAIS: 7All gestational ages
Tuckuviene et al102011Population-basedElectronic search of the Hospital Discharge Database of the Danish National Patient Registry, DenmarkAcutely (NAIS)NAIS: 52NAIS: 6All gestational ages
Present studyPopulation-basedProspective registration by the SNPSR via inquiry among child neurologists and neonatologistsAcutely (NAIS)NAIS: 100NAIS: 12>36 wk
  • a The study by Laugesaar et al included acutely and retrospectively diagnosed arterial ischemic and hemorrhagic stroke. They reported an overall incidence of 38 cases (12 were diagnosed acutely and 26 retrospectively), with an overall 63 cases per 100 000 live births. Because only 4 neonates had a diagnosis of arterial ischemic stroke in the neonatal period, the true incidence for NAIS was 6.7 cases per 100 000 live births.