TABLE 1

Absolute number (N), percentage (%), incidence rate (per million), Gender ratio, median age, and age-corrected AAPC (95% CI) by ICCC-3 subgroup for children Aged 0 to 14 Years Diagnosed With an Embryonal Tumor During 1991–2012 in Germany (N = 8337)

ICCC-33 Diagnostic SubgroupN%Incidence ratesGender Ratio Male/FemaleMedian Age (y, mo)AAPC % (95% CI)
Age SpecificASR12
01–45–910–140–14
III(c), Intracranial and intraspinal embryonal tumors193023.110.99.68.23.87.51.65, 10−1.1 (–1.8 to –0.3)a
 Boys120011.211.810.34.49.15, 11−0.8 (–1.7 to –0.1)a
 Girls73010.67.25.93.15.95, 9−1.5 (–2.7 to –0.3)a
III(c)1, Medulloblastomas142017.03.76.27.03.25.41.86, 9−0.3 (–1.2 to 0.5)
 Boys9094.17.98.83.96.76, 7−0.2 (–1.3 to 0.8)
 Girls5113.44.35.12.64.06, 11−0.6 (–1.9 to 0.8)
III(c)2, PNET3153.82.62.20.90.51.31.43, 7−4.3 (–6.0 to –2.6)
 Boys1822.02.51.20.41.44, 2−3.7 (–6.0 to –1.4)
 Girls1333.21.90.50.51.12, 11−5.1 (–7.8 to –2.4)
III(c)3, Medulloepithelioma170.21, 11
 Boys71, 6
 Girls106, 0
III(c)4, AT/RTb1782.17.92.00.50.11.41.31, 46.1 (2.0 to 10.4)
 Boys1028.62.30.50.11.61, 44.6 (–0.7 to 10.1)
 Girls767.21.70.50.11.31, 48.2 (1.8 to 15.0)
IV(a), Neuroblastoma and ganglioneuroblastoma298935.977.320.52.80.813.71.21, 30.2 (–0.4 to 0.8)
 Boys162182.621.72.80.814.51, 30.5 (–0.3 to 1.2)
 Girls136871.719.32.70.812.81, 3−0.1 (–0.9 to 0.7)
 Neuroblastoma284434.176.819.32.30.713.11.21, 20.2 (–0.4 to 0.7)
  Boys156182.020.72.60.614.01, 30.5 (–0.2 to 1.3)
  Girls128371.317.82.10.712.11, 2−0.3 (–1.2 to 0.6)
 Ganglioneuroblastoma1451.70.51.20.40.20.60.74, 01.0 (–1.6 to 3.6)
  Boys600.61.00.20.20.54, 0−1.9 (–5.7 to 2.2)
  Girls850.41.40.60.20.73, 103.0 (–0.4 to 6.6)
V, Retinoblastoma87910.523.66.60.40.14.11.11, 20.5 (–0.5 to 1.6)
 Boys45524.06.60.30.14.11, 21.4 (0 to 2.9)
 Girls42423.26.50.50.04.01, 2−0.4 (–1.9 to 1.1)
VI(a)1, Nephroblastoma (Wilms tumor)216025.920.718.95.20.79.40.93, 20.5 (–0.1 to 1.2)
 Boys102623.017.34.30.68.72, 100.2 (–0.8 to 1.1)
 Girls113418.420.66.10.810.03, 60.8 (–0.1 to 1.8)
VII(a), Hepatoblastoma3514.28.02.90.20.11.61.61, 44.6 (2.9 to 6.4)
 Boys2179.63.50.20.21.91, 43.5 (1.3 to 5.7)
 Girls1346.32.30.20.01.31, 36.6 (3.7 to 9.5)
XII(a)2, Pancreatoblastoma70.15, 0
 Boys2
 Girls5
XII(a)3, Pulmonary blastoma and pleuropulmonaryblastoma210.33, 0
 Boys133, 0
 Girls83, 0
All embryonal tumors8337100.0140.658.716.85.536.41.23, 20.3 (–0.1 to 0.6)
 Boys4534150.561.218.06.138.53, 20.3 (–0.1 to 0.8)
 Girls3803130.256.115.54.834.23, 20.1 (–0.4 to 0.7)
  • Dash indicates insufficient data.

  • a Without AT/RT, which has been recognized a distinct disease entity only since 1996.

  • b Data from 2000 to 2012.