Diagnostic Criteria

Essential FeaturesImportant FeaturesAssociated Features
Both must be presentAdd support to the diagnosis, observed in most cases of ADSuggestive of AD, but too nonspecific to be used for defining or detecting AD in research or epidemiologic studies
 1. Pruritus 1. Early age of onset 1. Atypical vascular responses (eg, facial pallor, white dermographism, delayed blanch response)
 2. Eczema (acute, subacute, chronic) 2. Atopy 2. Keratosis pilaris/pityriasis alba/hyperlinear palms/ichthyosis
  a. Typical morphology and age-specific patterns  a. Personal and/or family history 3. Ocular/periorbital changes
   •Infants/children: facial, neck, and extensor involvement  b. IgE reactivity 4. Other regional findings (eg, perioral changes/periauricular lesions)
   •Any age group: current or previous flexural lesions 3. Xerosis 5. Perifollicular accentuation/lichenification/prurigo lesions
   •Sparing of the groin and axillary regions
  b. Chronic or relapsing history
Exclusionary Conditions
Diagnosis of AD depends on excluding conditions
•Scabies•Seborrheic dermatitis•Photosensitivity dermatoses
•Psoriasis•Contact dermatitis (irritant or allergic)•Immune deficiency diseases
•Ichthyoses•Cutaneous T-cell lymphoma•Erythroderma of other causes
  • AD, atopic dermatitis; IgE, immunoglobulin E. Adapted from Eichenfield et al.14