TABLE 1

Patient Characteristics

CaseAge, yGenderMedical/Psychological ComorbiditiesNeurologic DiagnosisTopiramate DosageED DiagnosisED SymptomsChange in Weight, kgPhysical ED SequelaeOrder of Symptom Onset
117FPostconcussive syndrome, MDD, alcohol/cannabis abuse, traumaDaily migraine with aura25 mg, twice dailyED not otherwise specifiedWt loss; restriction; binge/purge; laxative abuse−6.8None reportedHistory of ED, relapse after topiramate initiation
216FPOTSMigraine50 mg, twice dailyAnorexia nervosaWt loss; restriction; self-induced vomiting−22.7Amenorrhea, cold intolerance, orthostatic intolerance, dizziness, fatigue, abdominal pain, constipationED onset first
313FNoneVein of Galen malformation, treated with coiling, migraine25 mg, twice dailyAnorexia nervosaWt loss; restriction; nighttime binge eating−11.5Anergia, amenorrhea, sinus bradycardia, ST and T-wave changesTopiramate initiation first
418FPOTS, nonepileptic spellsChronic daily headache50 mg in the morning, 75 mg at nightED not otherwise specifiedWt loss; restriction; self-induced vomiting−9.1Orthostasis, oligomenorrheaTopiramate initiation first
516FPOTS, gastrointestinal mastocytosis, MDDMigraine150 mg dailyBulimia nervosaWt gain; restriction; binge eating+32.0None reportedTopiramate initiation first
617FPOTS, MDD, attention deficit/hyperactivity disorderHeadache50 mg dailyED not otherwise specifiedWt loss; restriction; self-induced vomiting−6.8Nausea, cold intolerance, oligomenorrhea, dizziness, lightheadedness, abnormal bone density, multiple lower extremity fracturesED onset first
718FObsessive compulsive disorder, generalized anxiety disorderChronic daily headache with migrainous features50 mg dailyED not otherwise specifiedWt loss; restriction; self-induced vomiting−5.0Cold intolerance, fatigue, sleep challenges, oligomenorrhea, poor pain management, bruisingED onset first
  • MDD, major depressive disorder.