TABLE 4

Best-Fitting Multivariate Longitudinal Generalized Estimating Equation Models for Physician-Diagnosed Asthma and Active Wheeze From Ages 11–29 Years and LRIs During the First 3 Years of Life

LRIsSymptoms
AsthmaaActive Wheezeb
OR (95% CI)POR (95% CI)P
No LRIReferenceReference
Pneumonia1.95 (1.11–3.44).0211.94 (1.28–2.95).002
Other LRI1.30 (0.93–1.80).1221.37 (1.09–1.72).007
  • a Best-fitting model for asthma included age, LRIs, atopy at 6 years of age, current smoking, maternal asthma, paternal asthma, maternal smoking, paternal smoking, and paternal age. The number of observations for asthma outcome was 4150; the number of individuals included in the analysis was 738, with an average number of observations per individual of 5.6.

  • b Best-fitting model for active wheeze included age, LRIs, atopy at 6 years of age, current smoking, maternal asthma, paternal asthma, maternal smoking, paternal smoking, and maternal education. The number of observations for active wheeze outcome was 4160; the number of individuals included in the analysis was 738, with an average number of observations per individual of 5.6.