Table 4.

Drug Regimens for PCP Prophylaxis for Children 4 Weeks of Age or Older*28

Recommended regimen
 Trimethoprim-sulfamethoxazole, 150 mg/m2/d of trimethoprim with 750 mg/m2/d of sulfamethoxazole (or 5 mg/kg/d of trimethoprim with 25 mg/kg/d of sulfamethoxazole), orally in divided doses two times a day, 3 times per week on consecutive days (eg, Monday, Tuesday, and Wednesday)
Acceptable alternative trimethoprim-sulfamethoxazole dosage schedules
 150 mg/m2/d of trimethoprim with 750 mg/m2/d of sulfamethoxazole, orally as a single daily dose, 3 times
per week on consecutive days (eg, Monday, Tuesday,
and Wednesday)
 150 mg/m2/d of trimethoprim with 750 mg/m2/d of sulfamethoxazole, orally in divided doses two times a day, administered 7 days per week
 150 mg/m2/d of trimethoprim with 750 mg/m2/d of sulfamethoxazole, orally in divided doses two times a day, 3 times per week on alternate days (eg, Monday, Wednesday, and Friday)
Alternative regimens when therapy with trimethoprim-sulfamethoxazole is not tolerated
 Dapsone, 2 mg/kg (not to exceed 100 mg), orally once a day
 Aerosolized pentamidine (for children ≥5 y of age), 300 mg administered via Respirgard II inhaler, once a month
  • * PCP indicates Pneumocystis carinii pneumonia.

  • If neither dapsone nor aerosolized pentamidine is tolerated, some clinicians administer 4 mg/kg of pentamidine intravenously every 2 or 4 weeks.