TABLE 3

Odds of Becoming Overweight at the Age of 24 Months According to Age at First Exposure to Antibiotics and Number of Exposures <24 Months

Antibiotic ExposureBoysGirls
aOR95% CIaOR95% CI
Unexposed1.00Reference1.00Reference
Age at first exposure, mo
 Any antibiotics
  <61.34a1.06 to 1.661.160.87 to 1.56
  6–111.26a1.02 to 1.451.140.92 to 1.42
  12–171.180.88 to 1.321.080.85 to 1.38
  18–231.250.99 to 1.611.150.87 to 1.52
 Penicillins
  <61.280.99 to 1.621.200.87 to 1.66
  6–111.29a1.04 to 1.491.200.97 to 1.50
  12–171.280.95 to 1.421.040.81 to 1.33
  18–230.950.78 to 1.281.150.87 to 1.52
 Cephalosporins
  <61.440.97 to 2.351.250.67 to 2.35
  6–111.44a1.04 to 1.841.180.79 to 1.76
  12–171.46a1.06 to 1.821.270.88 to 1.82
  18–231.100.78 to 1.431.110.75 to 1.64
 Macrolides
  <61.65a1.09 to 2.311.530.90 to 2.60
  6–111.41a1.09 to 1.701.110.82 to 1.50
  12–171.100.84 to 1.341.280.95 to 1.71
  18–231.42a1.18 to 1.931.210.88 to 1.65
No. of exposures <24 mo
 Any antibiotics
  11.160.92 to 1.481.030.81 to 1.32
  2–31.28a1.04 to 1.591.140.91 to 1.42
  ≥41.27a1.04 to 1.551.190.96 to 1.48
 Penicillins
  11.130.90 to 1.411.110.89 to 1.40
  2–31.29a1.05 to 1.581.190.96 to 1.48
  ≥41.35a1.07 to 1.691.110.85 to 1.44
 Cephalosporins
  11.39a1.10 to 1.761.050.80 to 1.38
  ≥21.150.84 to 1.581.46a1.03 to 2.05
 Macrolides
  11.200.96 to 1.490.940.94 to 1.50
  ≥21.47a1.16 to 1.860.880.88 to 1.55
  • Statistical adjustments included maternal smoking after first trimester, parental relationship, mode of delivery, birth weight, and birth length for boys; maternal smoking after first trimester, mode of delivery, and birth weight for girls.

  • a P value <.05