Table 3.

Comparison of the Sensitivity of the Revised Reference Range32 and That of Manroe et al24 for Neutrophil Values in VLBW Neonates With Proven Sepsis

ATI†I:T†Manroe et alMouzinho et al
↓ATN↑ATNAny‡↓ATN↑ATNAny‡
All organisms
0–72 h (32 cases)
1st CBC (32 counts)95056375§13356
2nd CBC (27 counts)22677449622478
73–720 h (170 cases)
1st CBC (170 counts)433756482∥55877
2nd CBC (120 counts)49417688846585
GBS
0–72 h (19 cases)
1st CBC (19 counts)5585807416058
2nd CBC (16 counts)19816909425088
Coagulase-negative staphylococcus
73–720 h (78 cases)
1st CBC (78 counts)413046985¶46076
2nd CBC (52 counts)48276799047787
Gram-negative bacilli
73–720 h (26 cases)
1st CBC (26 counts)4250194689154689
2nd CBC (21 counts)4871144395144395
  • Values are the percent of counts outside the reference range.

  • The reference ranges for ATI and I:T values were the same using data of Manroe et al24 and that of Mouzinho et al.32

  • This indicates that at least one abnormal value was present from ATN, ATI and I:T values.

  • § P = .031, Manroe reference range vs Mouzinho reference range.

  • P = .002, Manroe reference range vs Mouzinho reference range.

  • P = .016, Manroe reference range vs Mouzinho reference range.