Table 2.

Selected Measures of the Occurrence and Treatment of Otitis Media During the First Two Years of Life According to Study Site Grouping

CharacteristicStudy Site Grouping (n)P Value*
Urban (634)Small Town/Rural (951)Suburban (668)Total (2253)
Mean (SD) no. of visits
 First year of life12.0 (2.5)12.5 (3.1)12.3 (2.8)12.3 (2.9).02
 Second year of life13.2 (3.0)14.2 (2.9)14.2 (3.2)13.9 (3.1)<.001
No. (%) of subjects with MEE at earliest visit after age 2 mo§132 (20.8)95 (10.0)47 (7.0)274 (12.2)<.001
No. (%) of subjects developing ≥1 episode of MEE between age 2 mo and age:
 6 mo387 (61.0)437 (46.0)253 (37.9)1077 (47.8)<.001
 12 mo536 (84.5)727 (76.4)515 (77.1)1778 (78.9)<.001
 24 mo592 (93.4)860 (90.4)601 (90.0)2053 (91.1).06
Mean (SD)/median cumulative percent of days with MEE
  First year of life27.7 (22.2)/23.419.0 (18.2)/14.815.4 (14.1)/12.520.4 (19.0)/15.7<.001
  Second year of life20.8 (20.3)/15.215.6 (15.6)/11.213.9 (13.9)/11.216.6 (16.8)/11.8<.001
Mean (SD)/median no. of days of antimicrobial treatment for otitis media
  First year of life48.9 (39.2)/4243.0 (49.5)/2833.7 (38.6)/2441.9 (44.0)/28<.001
  Second year of life43.7 (45.8)/2954.7 (68.8)/2844.5 (57.8)/2548.6 (60)/28.02
Mean (SD)/median no. of days of antimicrobial treatment for all reasons
  First year of life50.8 (39.6)/4344.9 (49.7)/2835.7 (39.6)/2643.8 (44.5)/31<.001
  Second year of life47.9 (46.8)/3458.5 (68.8)/3249.1 (58.9)/2952.7 (60.5)/31.046
No. (%) of subjects undergoing tympanostomy-tube operations
  First year of life19 (3.0)15 (1.6)6 (0.9)40 (1.8).01
  Second year of life37 (5.8)#37 (3.9)**20 (3.0)#94 (4.2).03
  • * Comparison regarding values between urban, small-town/rural, and suburban subgroups.

  • First year of life denotes the age period 2 to 12 mo.

  • MEE denotes middle-ear effusion; the term encompasses acute otitis media, secretory otitis media (otitis media with effusion), and tube otorrhea.

  • § In addition, a total of 29 subjects were noted to have MEE before age 2 mo that was no longer present at the first visit after age 2 mo.

  • Difference between mean values.

  • Difference between median values.

  • # One infant underwent operation twice.

  • ** One infant underwent operation three times.