TABLE 2

Relation of WMA Severity on Near Term Brain MRI to Neurodevelopmental Outcomes at 18 to 22 Months

Outcome at 18–22 mo Corrected AgeSeverity of WMA
Normal, n = 98Mild, n = 261Moderate, n = 68Severe, n = 18P
Cognitive score, mean ± SD93.5 (14.0)92.6 (13.1)89.9 (15.3)77.7 (14.5)<.0001
Cognitive score <704/98 (4.1)11/258 (4.3)7/67 (10.5)4/18 (22.2).011
Cognitive score <8520/98 (20.4)47/258 (18.2)20/67 (29.9)11/18 (61.1).0001
Any CP2/98 (2.0)14/261 (5.4)4/68 (5.9)11/18 (61.1)<.0001
Moderate to severe CP0/983/261 (1.2)1/68 (1.5)9/18 (50.0)<.0001
NDI4/98 (4.1)16/258 (6.2)7/67 (10.5)11/18 (61.1)<.0001
Significant gross motor impairment1/98 (1.0)5/261 (1.9)1/68 (1.5)10/18 (55.6)<.0001
Unimpaired/mildly impaired69/98 (70.4)176/258 (68.2)40/67 (59.7)3/18 (16.7)<.0001
NDI or death4/98 (4.1)25/267 (9.4)11/71 (15.5)13/20 (65.0)<.0001
  • Data presented as n/N (%) unless otherwise specified.