TABLE 5

Major Late CUS Findings and Neurodevelopmental Outcomes at 18 to 22 Months’ Corrected Age

Late CUS
Outcome at 18–22 mo Corrected AgeNormal, N = 321All Without Porencephalic Cyst, cPVL, Moderate to Severe VE, or Shunt, N = 419Porencephalic Cyst, cPVL, Moderate to Severe VE, or Shunt, n = 26Pa
Cognitive score, mean ± SD92.8 (13.2)92.4 (13.5)82.0 (18.2).0002
Cognitive score <7013/317 (4.1)20/415 (4.8)6/26 (23.1).0024
Cognitive score <8560/317 (18.9)84/415 (20.2)14/26 (53.9)<.0001
Any CP11/321 (3.4)17/419 (4.1)14/26 (53.9)<.0001
Moderate to severe CP1/321 (0.3)4/419 (1.0)9/26 (34.6)<.0001
NDI17/317 (5.4)25/415 (6.0)13/26 (50.0)<.0001
Significant gross motor impairment4/321 (1.3)7/419 (1.7)10/26 (38.5)<.0001
Unimpaired/mildly impaired220/317 (69.4)281/415 (67.7)7/26 (26.9)<.0001
NDI or death22/322 (6.8)38/428 (8.9)15/28 (53.6)<.0001
  • Data presented as n/N (%) unless otherwise specified.

  • a P values reflect comparisons between those with and without late CUS composite adverse finding (porencephalic cyst, cPVL, moderate to severe VE, or shunt).