TABLE 2

Association of Birth Size Measures With Late-Life ICV and Brain Volumes (in mL) in 1254 Older Participants

ICVTB VolumeWM VolumeGM VolumeCSF VolumeLn WML Volume
Birth weight (per SD decrease)
 Model
  1−25.9 (−32.0 to −19.8)**−17.6 (−22.3 to −12.9)**−7.5 (−9.7 to −5.2)**−9.8 (−12.9 to −6.8)**−8.3 (−12.1 to −4.5)**−0.02 (−0.06 to 0.03)
  2−25.0 (−31.1 to −19.0)**−17.1 (−21.7 to −12.4)**−7.2 (−9.4 to −4.9)**−9.6 (−12.6 to −6.6)**−8.0 (−11.8 to −4.2)**−0.01 (−0.06 to 0.04)
  3−20.3 (−26.5 to −14.1)**−13.4 (−18.2 to −8.6)**−5.9 (−8.2 to −3.6)**−7.2 (−10.3 to −4.1)**−6.9 (−10.8 to −2.9)**−0.02 (−0.07 to 0.04)
  4NA−1.3 (−4.4 to 1.7)−0.5 (−2.1 to 1.1)−1.0 (−3.6 to 1.5)−1.3 (−4.4 to 1.7)0.02 (−0.03 to 0.07)
Birth-length (per SD decrease)
 Model
  1−18.8 (−25.1 to −12.6)**−10.7 (−15.5 to −5.9)**−4.5 (−6.8 to −2.2)**−5.9 (−9.0 to −2.8)**−8.2 (−12.0 to −4.3)**0.00 (−0.05 to 0.05)
  2−18.2 (−24.3 to −12.0)**−10.3 (−15.0 to −5.5)**−4.3 (−6.5 to −2.0)**−5.8 (−8.8 to −2.7)**−8.0 (−11.7 to −4.1)**0.00 (−0.05 to 0.05)
  3−13.3 (−19.5 to −7.0)**−6.4 (−11.2 to −1.5)*−2.8 (−5.1 to −0.5)*−3.4 (−6.5 to −0.3)*−6.9 (−10.8 to −2.9)**0.01 (−0.05 to 0.06)
  4NA1.6 (−1.5 to 4.6)0.8 (−0.8 to 2.4)0.7 (−1.8 to 3.1)−1.6 (−4.6 to 1.5)0.03 (−0.02 to 0.08)
PI (per SD decrease)
 Model
  1−8.5 (−14.9 to −1.9)*−8.9 (−14.1 to −3.8)**−4.1 (−6.6 to −1.7)**−4.8 (−8.1 to −1.5)**−0.4 (−4.6 to 3.8)−0.02 (−0.07 to 0.04)
  2−8.2 (−14.6 to −1.9)*−8.8 (−13.9 to −3.7)**−4.1 (−6.5 to −1.7)**−4.8 (−8.1 to −1.5)**−0.3 (−4.5 to 3.8)−0.02 (−0.07 to 0.04)
  3−7.5 (−13.7 to −1.3)*−8.2 (−13.2 to −3.2)**−4.0 (−6.4 to −1.6)**−4.2 (−7.5 to −1.0)*−0.1 (−4.3 to 4.1)−0.02 (−0.07 to 0.03)
  4NA−3.3 (−6.5 to −0.1)*−1.8 (−3.5 to −0.1)*−1.7 (−4.3 to 0.8)*3.3 (0.1 to 6.5)*−0.01 (−0.06 to 0.05)
  • Data are presented as βs (95% CIs). Birth weight SD = 545 g; birth length SD = 2.5 cm; PI SD = 3.4 kg/m3. Model 1: adjusted for age and gender; model 2: additionally adjusted for education; model 3: additionally adjusted for midlife weight and height; and model 4: additionally adjusted for ICV. *P < .05,** P < .01. Ln, log normal; NA, not applicable.