Important Risk Factors for Severe Hyperbilirubinemia

Predischarge TSB or TcB measurement in the high-risk or high-intermediate–risk zone
Lower gestational age
Exclusive breastfeeding, particularly if nursing is not going well and weight loss is excessive
Jaundice observed in the first 24 h
Isoimmune or other hemolytic disease (eg, G6PD deficiency)
Previous sibling with jaundice
Cephalohematoma or significant bruising
East Asian race