TABLE 1

The Absorption and Excretion of Topically Applied 5% Sodium Fluoride Varnish to the Teeth of 6 12- to 15-Month-Old Children

PatientGenderAge (mo)Weight (kg)EPA + RfD + NOAEL (mg)Fapplied (mg)Time (min)volurine (mL)Furine (μg)Mean[F]plasmaa (μg/L)Peak[F]plasmaa (μg/L)
AM1211.00.66GGG299tx1671063082
ctl2669627
BM159.50.570.29444tx3151202672
ctl369388.2
CM1410.10.610.22318tx721002979
ctl129205.7
DF138.60.520.21225tx245209.426
ctl16262.8
EF159.90.590.18280tx48401337
ctl876522
FF159.60.580.22250tx171542157
ctl2253011
Mean + (SD)9.8 + (0.8)0.59 + (0.05)0.22 + (0.04)303 + (77)tx170 + (101)73 + (41)21 + (8)59 + (23)
ctl206 + (102)43 + (33)13 + (9)
  • ctl, control; EPA, Environmental Protection Agency; NOAEL, no observable adverse effect level; RfD, EPA oral reference dose; tx, treatment.

  • Saliva contamination obfuscated measurement of Fapplied for the first participant.

  • a Estimated from urine fluoride using the previous study7 as in Fig 1.