TABLE 3

HRs for Associations Between other Perinatal and Familial Factors and VTE From Birth to Maximum Follow-up (1973–2010)

Model 1aModel 2bP
HR (95% CI)HR (95% CI)
Gender
 Male1.001.00
 Female1.74 (1.66–1.82)1.90 (1.81–2.00)<.001
Birth cohort
 1973–19791.001.00
 1980–19891.23 (1.16–1.30)1.26 (1.19–1.34)<.001
 1990–19991.64 (1.47–1.82)1.64 (1.47–1.83)<.001
 2000–20082.29 (1.80–2.91)2.52 (1.92–3.31)<.001
Fetal growth (SD)
 Less than –21.31 (1.18–1.46)1.21 (1.08–1.35).001
 −2 to less than –11.01 (0.94–1.08)0.99 (0.92–1.06).72
 −1 to <01.03 (0.97–1.09)1.02 (0.97–1.09).43
 0 to <11.001.00
 1 to <21.04 (0.96–1.13)1.03 (0.95–1.12).51
 ≥21.09 (0.95–1.26)1.03 (0.88–1.19).74
Multiple birth status
 Singleton1.001.00
 Multiple birth0.82 (0.68–0.97)0.82 (0.68–0.99).04
Birth order
 11.001.00
 21.02 (0.97–1.08)1.00 (0.95–1.06).98
 31.02 (0.94–1.10)0.98 (0.90–1.06).58
 ≥41.15 (1.04–1.28)1.11 (1.00–1.24).06
Maternal age at delivery (y)
 <201.30 (1.15–1.46)1.28 (1.14–1.45)<.001
 20–241.06 (1.00–1.12)1.05 (0.99–1.12).12
 25–291.001.00
 30–340.96 (0.90–1.02)0.96 (0.90–1.03).26
 35–400.98 (0.89–1.08)0.97 (0.88–1.07).56
 ≥400.95 (0.78–1.15)0.91 (0.74–1.12).39
Maternal marital status
 Married/cohabiting1.001.00
 Never married1.04 (0.98–1.11)1.03 (0.97–1.10).38
 Divorced/widowed1.19 (1.11–1.28)1.17 (1.08–1.25)<.001
Maternal education (y)
 ≤91.001.00
 10–110.98 (0.93–1.04)0.98 (0.92–1.04).46
 12–140.89 (0.83–0.96)0.90 (0.84–0.97).008
 ≥150.81 (0.73–0.89)0.81 (0.73–0.89)<.001
Paternal education (y)
 ≤91.001.00
 10–111.01 (0.95–1.07)0.99 (0.94–1.05).83
 12–140.93 (0.87–0.99)0.94 (0.87–1.00).06
 ≥150.89 (0.81–0.98)0.91 (0.83–1.00).06
VTE in a parent
 No1.001.00
 Yes2.50 (2.32–2.68)2.46 (2.29–2.65)<.001
VTE in a sibling
 No1.001.00
 Yes3.06 (2.53–3.69)2.84 (2.33–3.45)<.001
  • —, reference group.

  • a Adjusted for age, gender, birth cohort, fetal growth, multiple birth, birth order, maternal age, maternal marital status, maternal and paternal education, and family history of VTE in a parent or sibling.

  • b Excluding individuals with significant congenital anomalies or cerebral palsy and adjusted for the same variables as model 1, as well as diabetes, heart failure, asthma, pneumonia, cancer, and fracture.