TABLE 1

Annual Rates of Rotavirus-Coded and Diarrhea-Associated Health Care Utilization Among Children <5 Years of Age Before and After Rotavirus-Vaccine Introduction, According to Age Group and Health Care Setting

Age GroupRotavirus-Coded HospitalizationsDiarrhea-Associated HospitalizationsDiarrhea-Associated ED VisitsDiarrhea-Associated Outpatient VisitsCoverage
Rate, n/10 000 PYRate Reduction (95% CI), %Rate, n/10 000 PYRate Reduction (95% CI), %Rate, n/10 000 PYRate Reduction (95% CI),%Rate, n/10 000 PYRate Reduction (95% CI),%RV5a,%RV1b, %
<1 y
 2001–06c16ref65ref212ref1713refNANA
 2007–2008381 (77 to 84)5024 (20 to 27)2044 (1 to 6)16086 (5 to 7)64NA
 2008–2009478 (74 to 81)4530 (27 to 34)18513 (11 to 15)149913 (12 to 13)73NA
 2009–2010195 (93 to 96)3447 (45 to 50)13138 (37 to 40)119630 (30 to 31)6412
 2010–2011288 (85 to 90)3645 (43 to 48)14034 (32 to 36)121129 (29 to 30)6810
1 y
 2001–06c33ref96ref324ref2376refNANA
 2007–2008972 (69 to 76)5641 (38 to 44)28213 (11 to 15)22645 (4 to 5)23NA
 2008–2009974 (71 to 77)6038 (35 to 41)2988 (6 to 10)23551 (0 to 2)64NA
 2009–2010196 (95 to 97)3564 (62 to 66)19739 (37 to 41)182523 (23 to 24)721
 2010–2011487 (85 to 89)3959 (57 to 61)22032 (30 to 34)193319 (18 to 19)6412
2–4 y
 2001–2006c8ref32ref130ref871refNANA
 2007–2008272 (67 to 76)2134 (31 to 37)1199 (7 to 11)8710 (–1 to 1)0NA
 2008–2009626 (19 to 32)299 (5 to 13)155−19 (–21 to –17)984−13 (–14 to –12)8NA
 2009–2010189 (87 to 91)1749 (46 to 51)10519 (18 to 21)7949 (8 to 9)290
 2010–2011363 (59 to 67)2037 (35 to 40)1245 (3 to 7)8651 (0 to 1)530
<5 y
 2001–2006c14ref52ref185ref1348refNANA
 2007–2008475 (72 to 77)3533 (31 to 35)1699 (7 to 10)13033 (3 to 4)17NA
 2008–2009660 (58 to 63)3925 (23 to 27)188−2 (–3 to 0)1360−1 (–1 to 0)32NA
 2009–2010194 (93 to 95)2454 (52 to 55)12831 (30 to 32)107820 (20 to 20)453
 2010–2011380 (78 to 81)2747 (46 to 49)14522 (21 to 23)113916 (15 to 16)585
  • CI, confidence interval; ED, emergency department; NA, not applicable; PY, person-year; ref, reference group.

  • a Coverage was defined as receipt of at least 1 dose of RV5 by December 31, 2007; December 31, 2008; December 31, 2009; or December 31, 2010, in children who had been in the database since birth and for at least 3 mo continuously. Coverage for children <1 y of age was restricted to those who were eligible for vaccination (ie, aged those 3–11 mo).

  • b Coverage was defined as receipt of at least 1 dose of RV1 by December 31, 2009, or December 31, 2010, in children with the same criteria as defined for RV5 coverage. Because RV1 was not introduced until April 2008, coverage of RV1 begins with the first full season starting in 2009.

  • c For 2001–2006, the average annual rate for the time period is shown.