Darbe | Epo | ESA ^{a} | Placebo | Unadjusted | Adjusted for Gender, Maternal Education | ||||
---|---|---|---|---|---|---|---|---|---|
n = 27 | n = 29 | P ^{*} | n = 56 | n = 24 | Odds Ratio (95% CI) | P ^{*} | Odds Ratio (95% CI) | P ^{*} | |
Cognitive score <85 | 0 (0) | 3 (10.3) | 0.12 | 3 (5.4) | 6 (25.0) | 0.17 (0.04–0.75) | 0.02 | 0.18 (0.04–0.82) | 0.03 |
Cognitive score <80 | 0 (0) | 3 (10.3) | 0.12 | 3 (5.4) | 5 (20.8) | 0.22 (0.05–0.99) | 0.05 | 0.24 (0.05–1.13) | 0.07 |
Cognitive score <70 | 0 (0) | 1 (3.5) | 0.50 | 1 (1.8) | 2 (8.3) | 0.20 (0.02–2.32) | 0.20 | 0.24 (0.02–2.93) | 0.26 |
NDI, ^{b} N (%) | 3 (11.1) | 4 (13.8) | 0.88 | 7 (12.5) | 10 (41.7) | 0.20 (0.06–0.62) | 0.005 | 0.21 (0.07–0.68) | 0.009 |
CP, ^{c} | 0 (0) | 0 (0) | 1.00 | 0 (0) | 5 (20.8) | N/A | 0.002 | N/A | <0.001 |
Visual deficit | 2 (7.4) | 0 (0) | 0.27 | 2 (3.6) | 1 (4.2) | 0.85 (0.07–9.87) | 0.91 | 0.72 (0.06–8.74) | 0.80 |
Hearing deficit | 0 (0) | 1 (3.5) | 0.50 | 1 (1.8) | 1 (4.2) | 0.42 (0.03–6.98) | 0.54 | 0.48 (0.03–8.59) | 0.62 |
NDI or death, N (%) | 4/28 (14.3) | 5/30 (16.7) | 0.92 | 9/58 (15.5) | 13/27 (48.2) | 0.20 (0.07–0.56) | 0.002 | 0.22 (0.07–0.70) | 0.01 |
Moderate NDI, ^{d} N (%) | 3 (11.1) | 2 (6.9) | 0.45 | 5 (8.9) | 9 (37.5) | 0.16 (0.05–0.56) | 0.004 | 0.18 (0.05–0.63) | 0.008 |
Moderate NDI or death, N (%) | 4/28 (14.3) | 3/30 (10.0) | 0.48 | 7/58 (12.1) | 12/27 (44.4) | 0.17 (0.06–0.51) | 0.002 | 0.20 (0.06–0.67) | 0.009 |
↵ * P values for comparisons between Darbe and Epo were computed using 2 methods depending on characteristics of the data. For the NDI measures, P values were computed using logistic regression with gender and maternal education as covariates. For the remaining measures, P values were computed using ANCOVA with only gender as a covariate. Percentages for NDI or death include deaths during initial hospitalization. CI, confidence interval. N/A, not applicable.
↵ ^{a} Treated groups are combined.
↵ ^{b} NDI is defined as having either CP, visual deficit, hearing deficit, or a cognitive score <85.
↵ ^{c} Given the absence of CP cases in the ESA treatment group, odds ratios cannot be accurately estimated. P values given for CP were computed using Fisher’s exact tests for the unadjusted P value and using ANCOVA with gender as the only covariate for the remaining P values.
↵ ^{d} Moderate NDI is defined as having either CP, visual deficit, hearing deficit, or a cognitive score <70.