TABLE 2

Infants Treated With Short Course Versus Longer Course of Antibiotics

VariableShort Course (n = 420)Longer Course (n = 134)P
Gestational age, mean ± SD, wk39.4 ± 1.339.2 ± 1.6.2
Male gender232 (55)67 (50).3
African-American race193 (46)67 (50).5
GBS colonization107 (25)19 (14).01
ROM >18 h136 (32)48 (36).5
Apgar at 5 min (median, range)9 (1–10)9 (1–9)<.001
Signs and symptoms suggestive of sepsis022 (16)<.001
Abnormal IT ratio at 12 h13 (3.1)70 (52.2)<.001
Abnormal CRP at 12 h26 (6.2)95 (70.9)<.001
Abnormal CRP ± IT ratio at 12 h35 (8.3)118 (88.1)<.001
Abnormal CRP + IT ratio at 12 h3 (0.7)52 (38.8)<.001
Lumbar puncture17 (4)103 (77)<.001
Days of hospitalization, mean ± SD3.5 ± 2.59.1 ± 8.1<.001
  • Unless otherwise indicated, data are presented as n (%). GBS, group B streptococcus; ROM, rupture of membranes.