TABLE 4

Projected Health Benefits of Existing and Hypothetical Otitis Media Vaccines for 4.2 Million Healthy US Infants

Disease OutcomeaNo. of Outcomes in the Case of No VaccinationNo. (%) of Outcomes Prevented by
PCV7 VaccinePneumo-NTH Combination VaccinePneumo-NTH–Moraxella Combination Vaccine
AOM episodesb13 741 000878 000 (6.4)3 726 000 (27.1)4 170 000 (30.4)
OME episodes214 00014 000 (6.6)55 000 (25.8)63 000 (29.3)
Tympanostomy-tube insertion350 00042 000 (11.9)155 000 (44.1)172 000 (49.3)
QALYs lostc210 00027 000 (13.1)71 000 (34.1)78 000 (37.3)
  • Projections are based on logistic regression and decision-analysis models that use data from Northern California Kaiser Permanente and other sources.

  • a Disease outcomes occurring in future years are discounted at 3%.

  • b Each episode was assumed to result, on average, in 1.2 outpatient visits.

  • c Includes loss of health-related quality of life because of AOM, medically attended OME, tympanostomy-tube insertion, pneumonia, meningitis, bacteremia, and death.