TABLE 5

Summary of Meta-analyses

OutcomesNumber of StudiesNumber of ParticipantsStatistical MethodEffect Size (95% CI)
Comparison 1: BoNT-A and OT versus OT alone
 QUEST, total score postintervention4108SMD (IV, fixed, 95% CI)0.35 (−0.03 to 0.73)
 QUEST, total score 6 to 8 months postintervention4108SMD (IV, fixed, 95% CI)0.06 (−0.32 to 0.44)
 Melbourne, 6 months postintervention242SMD (IV, fixed, 95% CI)−0.00 (−0.61 to 0.61)
 COPM-performance, postintervention3101SMD (IV, fixed, 95% CI)0.30 (−0.09 to 0.70)
 COPM-performance, 6 months postintervention279SMD (IV, fixed, 95% CI)0.12 (−0.32 to 0.57)
 COPM-satisfaction, postintervention3101SMD (IV, fixed, 95% CI)0.29 (−0.10 to 0.68)
 COPM-satisfaction, 6 months postintervention279SMD (IV, fixed, 95% CI)0.08 (−0.36 to 0.53)
 GAS, postintervention4144SMD (IV, fixed, 95% CI)0.92 (0.57 to 1.27)
 GAS, 6 to 9 months postintervention4144SMD (IV, random, 95% CI)0.56 (−0.01 to 1.13)
 PEDI Self-Care FSS, post intervention3112SMD (IV, random, 95% CI)−0.03 (−0.74 to 0,69)
 PEDI Self-Care FSS, 6 months postintervention3112SMD (IV, random, 95% CI)0.06 (−0.3 to 0.42)
Comparison 2: CIMT or mCIMT versus control (unequal dose) or comparison (equal dose)
 QUEST-Grasp, postintervention
  a) Comparison equal dose2114SMD (IV, fixed, 95% CI)0.11 (−0.26 to 0.47)
  b) Control (unequal dose)31370.30 (−0.04 to 0.64)
  Total52410.21 (−0.04 to 0.46)
 QUEST-Grasp, 6 months postintervention
  a) Comparison equal dose2114SMD (IV, fixed, 95% CI)0.07 (−0.29 to 0.44)
  b) Control (unequal dose)21060.18 (−0.21 to 0.56)
  Total42200.12 (−0.14 to 0.39)
 BOTMP-8, postintervention
  a) Comparison equal dose243SMD (IV, random, 95% CI)0.82 (0.12 to 1.52)
  b) Control (unequal dose)2381.95 (−1.01 to 4.92)
  Total4811.21 (0.23 to 2.19)
 BOTMP-8, 3 to 6 months postintervention
  a) Comparison equal dose243SMD (IV, random, 95% CI)0.88 (−0.28 to 2.04)
  b) Control (unequal dose)2384.14 (−4.07 to 12.34)
  Total4811.61 (0.02 to 3.20)
 AHA, postintervention
  a) Comparison equal dose2104SMD (IV, random, 95% CI)−0.04 (−0.42 to 0.35)
  b) Control (unequal dose)41230.13 (−0.39 to 0.66)
  Total61270.07 (−0.23 to 0.37)
 AHA, 6 months postintervention
  a) Comparison equal dose2100SMD (IV, random, 95% CI)−0.09 (−0.48 to 0.30)
  b) Control (unequal dose)2840.10 (−0.72 to 0.92)
  Total41840.02 (−0.34 to 0.37)
 COPM-performance, postintervention
  a) Comparison equal dose279SMD (IV, fixed, 95% CI)−0.13 (−0.58 to 0.31)
  b) Control (unequal dose)2840.05 (−0.38 to 0.48)
  Total4163−0.04 (−0.35 to 0.27)
 COPM-satisfaction, postintervention
  a) Comparison equal dose279SMD (IV, fixed, 95% CI)−0.24 (−0.68 to 0.20)
  b) Control (unequal dose)284−0.03 (−0.46 to 0.39)
  Total4163−0.13 (−0.44 to 0.18)
  • BOTMP-8, Bruininks-Oseretsky Test of Motor Proficiency subtest 8; FSS, Functional Skills Scale; GAS, Goal Attainment Scale; IV, .