TABLE 3

Risk of Comoribidities at Time of Bariatric Surgery Attributed to Weight Status at Age 18a

Weight Status at Age 18
NormalOverweightClass 1Class2/3Pb
Venous edema1 (reference)2.20 (1.38–3.51)3.02 (1.64–5.56)5.35 (2.57–11.14)<.0001
Severe walking limitation1 (reference)2.16 (1.37–3.42)1.60 (0.81–3.18)4.21 (2.13–8.35)<.001
Abnormal kidney function1 (reference)1.49 (0.97–2.28)1.83 (1.05–3.20)4.02 (2.52–6.42)<.0001
PCOS (women only)1 (reference)1.46 (0.99–2.16)1.75 (1.14–2.69)1.74 (1.06–2.89).06
Ischemic heart disease1 (reference)1.37 (0.87–2.17)1.63 (0.87–3.07)1.53 (0.64–3.63).39
Asthma1 (reference)1.02 (0.82–1.28)1.25 (0.97–1.61)1.48 (1.08–2.02).051
Diabetes1 (reference)1.07 (0.90–1.27)1.37 (1.12–1.66)1.42 (1.09–1.84)<.01
Microalbuminaria1 (reference)0.93 (0.66–1.31)0.96 (0.61–1.52)1.35 (0.82–2.22).47
Obstructive sleep apnea1 (reference)1.05 (0.95–1.16)1.20 (1.08–1.34)1.25 (1.09–1.44)<.001
Hypertensionc
 Women at age 46 y1 (reference)1.07 (0.95–1.20)1.16 (1.005–1.34)1.25 (1.05–1.50).04
 Men at age 46 y1 (reference)1.12 (0.96–1.32)1.42 (1.16–1.73)1.02 (0.78–1.32)<.01
Dyslipidemia1 (reference)1.13 (0.99–1.29)1.02 (0.90–1.15)1.05 (0.92–1.19).06
Urinary incontinence1 (reference)0.99 (0.87–1.12)0.93 (0.79–1.10)1.05 (0.84–1.32).78
Hyperlipidemia1 (reference)0.86 (0.75–0.98)0.95 (0.81–1.13)0.62 (0.45–0.86).01
  • a Relative risks and 95% CIs for weight status are adjusted for age and change in BMI, which were centered at their mean; gender and race, if significantly related to the outcome; and significant interactions. Models for abnormal kidney function and microalbuminuria also controlled for diabetes and hypertension status.

  • b P value for overall effect.

  • c There was a significant interaction between weight status at age 18 and both gender and age. Relative risks are presented at mean age, 46 y.