TABLE 3

Characteristics Associated With Prolonged Initial Empirical Antibiotic Treatment

Prolonged Initial Empirical Antibiotic TreatmentP
No (N = 1892)Yes (N = 2147)
Maternal demographic features
    Married, n (%)873 (47)914 (43).02
    Gravida, mean ± SD2.62 ± 1.882.87 ± 2.05<.001
    Multiple gestation, n (%)459 (24)435 (20).002
    Hypertension, n (%)539 (29)422 (20)<.001
    Prenatal steroid treatment, n (%)1538 (82)1685 (79).02
    >1 course of prenatal steroid treatment, n (%)144 (8)131 (6).07
    Intrapartum antibiotic treatment, n (%)1213 (64)1515 (71)<.001
    Rupture of membranes for >24 h, n (%)336 (18)569 (27)<.001
    Cesarean section, n (%)1207 (64)1184 (55)<.001
Neonatal demographic features
    Birth weight, mean ± SD, g790 ± 139752 ± 144<.001
    Gestational age, mean ± SD, wk26.3 ± 2.0125.6 ± 1.89<.001
    Female, n (%)1036 (55)1049 (49)<.001
    Race, n (%)
        Black783 (42)1031 (48)<.001
        White771 (41)762 (35)
        Hispanic270 (14)299 (14)
        Other62 (3)53 (2)
    Small for gestational age, n (%)366 (19)308 (14)<.001
    5-min Apgar score of <5, n (%)205 (11)391 (18)<.001
  • Variables tested but not associated with prolonged initial empirical antibiotic treatment with P < .1 included maternal age of <25 years, prenatal care (defined as ≥1 visit before delivery), maternal diabetes mellitus, maternal hemorrhage, completed ≥1 course of prenatal steroid treatment, and maternal use of tocolytics.