Randomized Controlled Trials of Antimicrobial Therapy for Subacute Sinusitis

Author (Year)Age (y)Inclusion CriteriaAntimicrobial AgentsLengthOther TreatmentsNBetter (%)Worse or Same (%)Jadad Score
El-Hennawi et al (2006)25<2Persistent nasal discharge and nasal obstruction for 30–90 dAmoxicillin-clavulanate (40 mg/kg per day)14 dAll had therapeutic nasal suction every third day3064362
Culture-based (nasal suction)30
Amoxicillin/clavulanate (40 mg/kg per day)128317
Amoxicillin/clavulanate (90 mg/kg per day)14 d61000
Other antibiotics51000
No antibiotics (negative culture result)45050
Ng et al (2000)265–16Nasal discharge or blockage for 30–120 d and abnormal sinus radiographAzithromycin (10 mg/kg per day)3 dAll received budesonide nasal spray 50 µg/nostril 2 times/day for 91 d20NDa303
Amoxicillin/clavulanate (312 mg 3 times/day if aged ≤12 y or 375 mg 3 times/day if aged >12 y)14 d21NDa24
Dohlman et al (1993)272–16Mucoid nasal drainage, cough, or poorly controlled asthma for 3 wk–3 mo and abnormal sinus radiographAmoxicillin (30-40 mg/kg per day)21 dAll received oral phenylephrine, phenylpropanolamine, and guaifenesin; all received saline nasal spray2572283
Amoxicillin-clavulanate (30-40 mg/kg per day)21 d267327
TMP/SMX (8 mg/kg per day)21 d266931
  • ND, not determined; TMP/SMX, trimethoprim/sulfamethoxazole.

  • a This study only reported “failures.”