Aggregate evidence quality: B; randomized controlled trials with limitations.
BenefitIncrease clinical cures, shorten illness duration, and may prevent suppurative complications in a high-risk patient population.
HarmAdverse effects of antibiotics.
CostDirect cost of therapy.
Benefits-harm assessmentPreponderance of benefit.
Value judgmentsConcern for morbidity and possible complications if untreated.
Role of patient preferenceLimited.
Intentional vaguenessNone.
StrengthStrong recommendation.