TABLE 4

CP and Cognitive Delay of the Evaluated Infants Born at 22 and 23 Weeks’ Gestation From the Systematic Review

Study Name (Reference) (Location, Age at Follow-up, Year of Birth, Type of Study)22 Weeks23 Weeks24–27 Weeks
CP, n/Evaluated Infants (%)Cognitive Delay, n/Evaluated Infants (%)NDI, n/Evaluated Infants (%)CP, n/Evaluated Infants (%)Cognitive Delay, n/Evaluated Infants (%)NDI, n/Evaluated Infants (%)CP, n/Evaluated Infants (%)Cognitive Delay, n/Evaluated Infants (%)NDI, n/Evaluated Infants (%)
NICHD (7) (US, 18–24 mo, 2002–2004, multicenter)22–23 weeks; 28/105 (27)22–23 weeks; MDI <70: 63/102 (62); PDI <70: 46/104 (44)22–23 weeks; 72/103 (70)24 weeks; 57/298 (19)24 weeks; MDI <70: 133/282 (47); PDI <70 88/280 (31)24 weeks; 155/284 (55)
VON (8) (US, 18–24 mo, 1998–2003, multicenter)<23 weeks CP and/or cognitive delay; 11/15(73)<23 weeks; 11/15 (13)CP and/or cognitive delay; 112/214 (52)112/214 (52)24–25 weeks CP and/or cognitive delay; 495/1499 (33)24–25 weeks; 495/1229 (40)
Victoria (9,10) (Australia, 24 mo, 2005, population-based)22–27 weeks; 16/163 (10)22–27 weeks; 26/163 (16)24–27 weeks; 80/163 (49)
EPIBEL (11,12) (Belgium, 30–42 mo, 1999–2000, population-based)(All cases dead)(All cases dead)(All cases dead)0/1 (0)0/1 (0)0/1 (0)24–26 weeks; 19/77 (25)24-26 weeks; MDI <70: 22/77 (29); PDI <70: 37/77 (48)24–26 weeks; 51/88 (58)
EPICure 1 (13,14) (UK, 30 mo median, 1995, population-based)1/2 (50)22–23 weeks; 7/26 (27)14/25 (56)22–25 weeks; 50/306 (16)24–25 weeks; 78/257 (30)24–25 weeks; 136/279 (49)
EPIPAGE (15,16) (France, 24 mo, 1997, population-based)(All cases dead)(All cases dead)(All cases dead)(All cases dead)(All cases dead)(All cases dead)
Essen (17) (Germany, 24–30 mo, 2000–2004, hospital-based)1/2 (50)0/5 (0)24-25 weeks; 6/34 (18)
ETFOL (18) (Denmark, 24 mo, 1994–1995, population-based)(All cases dead)(All cases dead)(All cases dead)24–27 weeks; 5/53 (9)24–27 weeks; 9/53 (17)24–27 weeks; 52/183 (28)
Current study (Japan, 36 mo median, 2003–2005, multicenter)5/23 (22)12/21 (57)12/23 (52)21/118 (18)55/110 (50)65/114 (57)24–25 weeks; 49/407 (12)24–25 weeks; 107/360 (30)24–25 weeks; 131/354 (37)
  • EPIBEL, Extremely Preterm Infants in Belgium Study Group; EPICure, study for all infants born before 26 completed weeks of gestational age in the United Kingdom and the Republic of Ireland in 1995; EPIPAGE, The Etude Epidémiologique sur les Petits Ages Gestationnels study; MDI, mental developmental index; PDI, psychomotor developmental index; VON, Vermont Oxford Network; —, data was not shown.