TABLE 6

Comparison of Regional Brain Volumes According to Menstrual Function

Brain RegionMean ± SD, Volume per mLANOVA, PEffect Size (Cohen's d)
Amenorrhea or Irregular Menses AN (n = 14)Regular Menses or OCP AN (n = 46)Control (n = 34)a1 vs 32 vs 31 vs 2
Third ventricle2.1 ± 0.52.0 ± 0.41.8 ± 0.5.100.550.390.26
Lateral ventriclesb15.1 ± 5.015.4 ± 5.712.4 ± 5.2.050.510.54−0.06
Temporal hornsc3.6 ± 1.43.1 ± 1.02.8 ± 0.8.050.780.350.41
Hippocampic7.1 ± 0.87.1 ± 0.77.3 ± 0.9.64−0.24−0.18−0.08
  • Compared with control subjects, regular menses or OCP AN has greater lateral ventricle volumes (P = .05), and amenorrhea or irregular menses AN has greater temporal horn volumes (P = .05) (Tukey's HSD).

  • a Only control subjects who had regular menses or who were on OCP were included.

  • b Data show regular menses or OCP AN subjects (n = 45).

  • c Data show regular menses or OCP AN (n = 45) and control (n = 33) subjects.