TABLE 3

Total and Regional Brain Volumes

VariableMean ± SD volume/mLP (2-tailed)Effect Size (Cohen's d)
Adolescent AN (N = 60)Control (N = 37)
Gray matter
    Frontal, L157.2 ± 10.6159.2 ± 11.40.38−0.19
    Frontal, R152.9 ± 11.3153.2 ± 13.40.91−0.02
    Parietal, L83.6 ± 5.783.3 ± 7.70.830.05
    Parietal, R85.4 ± 10.884.6 ± 8.30.630.11
    Temporal, L108.8 ± 10.9107.0 ± 10.70.440.16
    Temporal, R110.6 ± 10.6107.1 ± 10.70.120.33
    Occipital, L50.2 ± 4.649.9 ± 4.90.740.07
    Occipital, R44.8 ± 4.344.9 ± 4.80.98−0.01
    Insula, L12.8 ± 0.913.0 ± 1.10.33−0.21
    Insula, R12.5 ± 0.912.4 ± 1.10.760.07
    Cingulate region, L21.7 ± 2.222.3 ± 1.80.15−0.30
    Cingulate region, R22.8 ± 2.123.6 ± 1.70.07−0.38
    Caudate nucleus, L6.7 ± 0.56.7 ± 0.50.450.16
    Caudate nucleus, R6.7 ± 0.56.6 ± 0.60.250.24
    Putamen, L8.6 ± 0.98.8 ± 1.10.36−0.19
    Putamen, R8.9 ± 1.09.3 ± 1.20.09−0.36
    Globus pallidus, L1.6 ± 0.21.7 ± 0.30.28−0.23
    Globus pallidus, R1.6 ± 0.21.6 ± 0.30.17−0.32
    Thalamus, L11.0 ± 0.710.7 ± 0.80.100.37
    Thalamus, R10.7 ± 0.610.5 ± 0.70.070.38
    Subthalamic nucleus, L0.1 ± 0.00.1 ± 0.00.53−0.13
    Subthalamic nucleus, R0.1 ± 0.00.1 ± 0.00.57−0.12
    Hippocampus, La3.6 ± 0.43.7 ± 0.50.34−0.20
    Hippocampus, Ra3.6 ± 0.43.7 ± 0.50.15−0.31
White matter
    Frontal, Lb95.0 ± 8.095.2 ± 9.00.93−0.02
    Frontal, Rb90.8 ± 7.689.9 ± 9.60.610.11
    Parietal, Lb44.2 ± 5.143.6 ± 6.20.430.17
    Parietal, Rb45.9 ± 5.845.3 ± 6.30.680.09
    Temporal, L47.7 ± 3.948.3 ± 6.00.52−0.14
    Temporal, R49.4 ± 4.549.0 ± 5.40.690.08
    Occipital, L18.3 ± 4.516.1 ± 3.70.930.05
    Occipital, R19.8 ± 4.919.9 ± 4.40.81−0.02
    Fornix, L1.0 ± 0.11.0 ± 0.10.06−0.11
    Fornix, R1.0 ± 0.11.0 ± 0.10.60−0.40
    Corpus callosum16.6 ± 2.717.1 ± 1.80.25−0.22
Brainstem/cerebellumc193.3 ± 13.7190.1 ± 16.90.300.22
CSF
    Third ventricle2.0 ± 0.41.8 ± 0.50.020.49
    Fourth ventricle0.1 ± 0.00.1 ± 0.00.74−0.07
    Subarachnoid space147.3 ± 19.4150.4 ± 17.80.44−0.16
    Lateral ventricle, Lb7.8 ± 3.96.6 ± 3.10.060.41
    Lateral ventricle, Rb7.5 ± 3.26.1 ± 2.50.030.48
    Temporal horn, La1.4 ± 0.61.3 ± 0.30.110.30
    Temporal horn, Ra1.8 ± 0.71.4 ± 0.50.010.53
Total gray matter919.4 ± 55.1916.5 ± 62.70.820.14
Total white matterb429.1 ± 35.6428.4 ± 44.80.930.21
Total CSFa164.7 ± 19.9165.3 ± 19.90.89−0.03
  • Only optimally processed images were included; N applies unless otherwise indicated; L indicates left; R, right.

  • a Data show adolescent AN (n = 59) and control (n = 36) subjects.

  • b Data show adolescent AN subjects (n = 59).

  • c Data are not included in total tissue volume calculations.