TABLE 2

Crude and Multivariate aHRs for Phototherapy and Covariates for at Least 1 Seizure Diagnosis Plus at Least 1 AED Prescription

VariableCrude HRPaHR (95% CI)P
Any phototherapy1.55<.0011.22 (1.05 to 1.42).009
Year of birth
 1995–2000Reference1
 2001–20061.03.571.01 (0.93 to 1.1).82
 2007–20111.05.440.98 (0.87 to 1.1).72
Maternal age in y, ≥250.94.0590.94 (0.86 to 1.02).16
Male sex1.20<.0011.18 (1.1 to 1.27)<.001
Race and/or ethnicity
 WhiteReference1
 Asian American0.84.0010.8 (0.72 to 0.9)<.001
 African American1.37<.0011.3 (1.15 to 1.47)<.001
 Hispanic0.95.250.94 (0.86 to 1.03).19
 Other0.72<.0010.71 (0.6 to 0.84)<.001
Down syndrome4.77<.0011.38 (0.82 to 2.33).23
Chromosomal anomaly other than trisomy 2124.7<.00116.42 (13.2 to 20.43)<.001
Congenital anomaly3.15<.0012.1 (1.77 to 2.49)<.001
Gestational age, wk
 351.96<.0011.33 (1.05 to 1.69).02
 361.63<.0011.29 (1.07 to 1.55).008
 371.20.0011.06 (0.92 to 1.24).42
 381.15.0211.08 (0.97 to 1.21).16
 391.09.0981.06 (0.97 to 1.17).19
 40Reference1
 410.96.530.92 (0.82 to 1.04).20
 ≥420.82.150.76 (0.55 to 1.05).098
Birth wt <2500 g2.00<.0011.28 (1.06 to 1.54).01
SGA1.31<.0011.14 (1.01 to 1.29).028
Delivery mode
 Spontaneous vaginalReference1
 Assisted vaginal1.09.1971.06 (0.93 to 1.2).41
 Cesarean1.23<.0011.13 (1.04 to 1.23).005
 Unspecified1.58<.0011.47 (0.95 to 2.29).086
5-min Apgar score <71.80.0091.4 (1.03 to 1.89).03
DAT result
 Not done0.86<.0010.95 (0.88 to 1.04).26
 NegativeReference1
 Positive1.00.970.98 (0.76 to 1.25).84
Maximum conjugated bilirubin ≥1 mg/dL2.62<.0011.43 (1 to 2.05).05
Maximum TSB, mg/dL
 <10Reference1
 10–14.91.11.141.03 (0.9 to 1.17).68
 15–19.91.14.211.07 (0.92 to 1.23).38
 20–24.91.45.0011.29 (0.99 to 1.69).061
 Not done0.91.160.98 (0.88 to 1.1).76
Meningitis1.61.261.41 (0.53 to 3.76).49
Birth asphyxia or hypoxic ischemic encephalopathy1.59.161.12 (0.64 to 1.94).69
Intracranial hemorrhage6.69<.0012.39 (1.12 to 5.1).024
  • aHR, adjusted hazard ratio; —, not applicable.