TreatmentnUrinary Free Cortisol Levels Corrected for Creatinine, μg/mg creatinineUrinary Free Cortisol Levels, μg/d
Baseline MeanChange From Baseline to Study End (95% CI)Baseline MeanChange From Baseline to Study End (95% CI)
24-h levelsa
    CIC401090.022−0.002 (−0.005 to 0)10.560.31 (−1.58 to 2.20)
    CIC160970.022−0.003 (−0.006 to 0)10.08−0.70 (−2.61 to 1.21)
    Placebo1020.023−0.002 (−0.004 to 0.001)11.37−0.24 (−2.08 to 1.61)
10-h levelsb
    CIC40710.023−0.001 (−0.006 to 0.003)4.651.39 (−0.28 to 3.06)
    CIC160910.020−0.003 (−0.007 to 0.001)3.82−0.03 (−1.51 to 1.45)
    Placebo750.020−0.000 (−0.005 to 0.004)5.091.20 (−0.42 to 2.83)
  • a Thirty-nine study centers were selected to collect and assess 24-hour urinary free cortisol levels.

  • b Thirty-six study centers were selected to collect and assess 10-hour overnight urinary free cortisol levels.